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http://ri.uaemex.mx/handle20.500.11799/71019| Title: | In vivo anti-inflammatory activity and acute toxicity of methanolic extracts from wild plant leaves and cell suspension cultures of Buddleja cordata Kunth (Buddlejaceae) | Authors: | GABRIEL ALFONSO GUTIERREZ REBOLLEDO MARIA ELENA ESTRADA ZUÑIGA AURELIO NIETO TRUJILLO FRANCISCO CRUZ SOSA MARIA ADELINA JIMENEZ ARELLANES |
Keywords: | cultivos de suspensión celular;Buddleja cordata;verbascósido;actividad antiinflamatoria;dosis letal media;info:eu-repo/classification/cti/1 | Publisher: | Revista Mexicana de Ingeniería Química | Project: | Vol.;17 No.;1 |
Description: | Buddleja cordata is a species used by Mexican folk medicine for treating illnesses related to inflammation such as skin wounds and arthritis. It bio-synthesizes metabolites such as verbascoside that contributes to its ethno-therapeutic properties as anti-inflammatory remedy. HPLC analysis showed that the methanolic extract from cell suspension cultures (Bc-Cc) and wild plant leaves (Bc-Wp) contained verbascoside, but concentration was higher in Bc-Cc (87.48 mg/g) than in wild plant (47.34 mg/g). In the acute toxicity model, none of the extracts generated any lethality or adverse eects. In acute inflammation model induced with TPA, Bc-Cc extract showed a greater edema inhibition at 2 mg/ear (61.72%), as well for carrageenan model at 200 mg/kg(48.87%). Bc-Wp showed lesser anti-inflammatory efect in both acute inflammation models than Bc-Cc. For Adjuvant-induced arthritis both extracts at 250 mg/kg generated a moderate inhibition over edema ( 33%) at day 28, and they were statistically no different to phenilbutazone. The culture in suspension of B. cordata obtained by biotechnological process contains greater amount of verbascosido and showed better anti-inflammatory activity; thus, representing a source for obtaining this type of secondary metabolite of pharmacological interest | URI: | http://ri.uaemex.mx/handle20.500.11799/71019 | Other Identifiers: | http://hdl.handle.net/20.500.11799/71019 | Rights: | info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 |
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