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Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/71028
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dc.contributor.authorMARIA GORETY JACOBO CEJUDOen_EU
dc.contributor.authorROSA VIRGEN PARDO MORALESen_EU
dc.contributor.authorBEATRIZ ELINA MARTINEZ CARRILLOen_EU
dc.contributor.authorLAURENCE S. HARBIGEen_EU
dc.contributor.authorROXANA VALDES RAMOSen_EU
dc.contributor.authorANA LAURA GUADARRAMA LOPEZen_EU
dc.creatorMARIA GORETY JACOBO CEJUDO-
dc.creatorROSA VIRGEN PARDO MORALES-
dc.creatorBEATRIZ ELINA MARTINEZ CARRILLO-
dc.creatorLAURENCE S. HARBIGE-
dc.creatorROXANA VALDES RAMOS-
dc.creatorANA LAURA GUADARRAMA LOPEZ-
dc.date2017-06-03-
dc.date.accessioned2019-03-12T23:44:09Z-
dc.date.available2019-03-12T23:44:09Z-
dc.identifierhttp://hdl.handle.net/20.500.11799/71028-
dc.identifier.urihttp://ri.uaemex.mx/handle20.500.11799/71028-
dc.descriptionArtículo derivado de un proyecto de investigación de Suplementación con ácidos grasos poliinsaturados n-3 y vitamina D en pacientes con diabetes mellitus tipo 2-
dc.descriptionAbstract: Background: Type 2 diabetes mellitus (T2DM) is accompanied by chronic low-grade inflammation, with an imbalance in the secretion of adipokines and, worsening insulin resistance. Supplementation with n-3 PUFA in T2DM decreases inflammatory markers, the purpose of the study was to investigate the effect of n-3 PUFA supplementation on adipokines, metabolic control, and lipid profile in T2DM Mexican adults. Methods: In a randomized, single-blind, placebo-controlled pilot study, 54 patients with T2DM received 520 mg of DHA + EPA-enriched fish-oil (FOG) or a placebo (PG) daily. Baseline and 24-week anthropometric and biochemical measurements included glucose, insulin, glycosylated hemoglobin (Hb1Ac), leptin, adiponectin, resistin, and lipid profile; n-3 PUFA intake was calculated in g/day. Results: Waist circumference and blood glucose showed significant reductions in the FOG group (p = 0.001 and p = 0.011, respectively). Hb1Ac (p = 0.009 and p = 0.004), leptin (p < 0.000 and p < 0.000), and leptin/adiponectin ratio (p < 0.000 and p < 0.000) decreased significantly in both groups after 24 weeks (FOG and PG respectively). Serum resistin (FOG p < 0.000 and PG p = 0.001), insulin (FOG p < 0.000 and PG p < 0.000), and HOMA-IR (FOG p = 0.000 and PG p < 0.000) increased significantly in both groups. FOG had an overall improvement in the lipid profile with a significant decrease in triacylgycerols (p = 0.002) and atherogenic index (p = 0.031); in contrast, the PG group had increased total cholesterol (p < 0.000), non-HDL cholesterol (p < 0.000), and atherogenic index (p = 0.017). Conclusions: We found a beneficial effect of n-3 PUFA supplementation on waist circumference, glucose, Hb1Ac, leptin, leptin/adiponectin ratio, and lipid profile, without significant changes in adiponectin, and increases in resistin, insulin, and HOMA-IR in both groups.-
dc.descriptionCONACyT, Desarrollo Científico para atender problemas nacionales, No. 212946-
dc.languageeng-
dc.publisherNutrients-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by/4.0-
dc.source20726643-
dc.subjectdiabetes mellitus tipo 2-
dc.subjectadipocinas-
dc.subjectperfil de lípidos-
dc.subjectn-3 PUFA-
dc.subjectinfo:eu-repo/classification/cti/3-
dc.titleEffect of n-3 polyunsaturated fatty acid supplementation on metabolic and inflammatory biomarkers in type 2 diabetes mellitus patients-
dc.typearticle-
dc.audiencestudents-
dc.audienceresearchers-
item.fulltextNo Fulltext-
item.grantfulltextnone-
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