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Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/105538
DC FieldValueLanguage
dc.creatorAngelica De La Cruz-
dc.creatorFERNANDO MEJIA SANCHEZ-
dc.creatorMaricela Hernández Serrano-
dc.creatorLaura Patricia Montenegro Morales-
dc.creatorJULIETA CASTILLO CADENA-
dc.date2019-06-12-
dc.date.accessioned2022-04-21T06:02:06Z-
dc.date.available2022-04-21T06:02:06Z-
dc.identifierhttp://hdl.handle.net/20.500.11799/105538-
dc.identifier.urihttp://ri.uaemex.mx/handle20.500.11799/105538-
dc.descriptionThe CYP3A4*2 polymorphism is rare in the population studied. Given the low frequency of CYP3A4*2 polymorphisms found in homozygous or heterozygous condition, it is advisable to consider the genotype of the patient before prescribing drugs metabolized by this gene.-
dc.descriptionVariability in response to drugs is a problem in clinical practice. The rate of patients who respond adequately to pharmacological therapy is generally around 60. The CYP450 multienzyme complex is a microsomal system located in the endoplasmic reticulum. The enzymes participate in phase I metabolism of xenobiotics. CYP3A4 is the isoenzyme mostly expressed in liver. Its gene is polymorphic, of which CYP3A4*1A is the wild allele and CYP3A4*2 is a polymorphism which consists of the S222P substitution in the amino acid sequence, affecting the activity of the enzyme. Methods: In this study, we determine the frequency of CYP3A4*2 polymorphism in Mexican individuals. 62 apparently healthy individuals, from Toluca de Lerdo, Mexico. The sample was 3 mL of peripheral blood. The DNA was extracted and PCR-RFLPs were performed. Results:58 individuals possess the wild allele in homozygosity CYP3A4*1A/CYP3A4*1A (94%) and 4 individuals were heterozygous CYP3A4*1A/CYP3A4*2 (6%). The homozygous polymorphic CYP3A4*2/CYP3A4*2 was not found in any individual.-
dc.descriptionCOMECYT-
dc.languageeng-
dc.publisherBiomedical Research-
dc.relation30-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.source0970-938X-
dc.subjectResearch Subject Categories-
dc.subjectResearch Subject Categories-
dc.subjectinfo:eu-repo/classification/cti/3-
dc.titleImportance of the identification of the CYP3A4*2 polymorphism for the prescription of pharmacological treatment-
dc.typearticle-
dc.audiencestudents-
dc.audienceresearchers-
item.grantfulltextnone-
item.fulltextNo Fulltext-
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