Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/39321
Title: A Therapeutic System of 177Lu-labeled Gold Nanoparticles-RGD Internalized in Breast Cancer Cells
Authors: MYRNA ALEJANDRA LUNA GUTIERREZ 
GUILLERMINA FERRO FLORES 
BLANCA ELI OCAMPO GARCIA 
CLARA LETICIA SANTOS CUEVAS 
ERIKA PATRICIA AZORIN VEGA 
KEILA ISAAC OLIVE 
Keywords: Química;Gold nanoparticles radiolabeled nanoparticles radio-gold nanoparticles radiolabeled peptides nanoparticle-peptide RGD pep- tide lutetium-177;info:eu-repo/classification/cti/2
Publisher: Sociedad Química de México
Project: http://www.redalyc.org/revista.oa?id=475 
Description: The aim of this research was to evaluate the in vitro potential of 177 Lu-labeled gold nanoparticles conjugated to cyclo-[RGDfK(C)] peptides ( 177 Lu-AuNP-c[RGDfK(C)]) as a plasmonic photothermal therapy and targeted radiotherapy system in MCF7 breast cancer cells. Peptides were conjugated to AuNPs (20 nm) by spontaneous reaction with the thiol group of cysteine (C). After laser irradiation, the pres - ence of c[RGDfK(C)]-AuNP in cells caused a significant increase in the temperature of the medium (50.5 °C, compared to 40.3 °C without AuNPs) resulting in a significant decrease in MCF7 cell viability down to 9 %. After treatment with 177 Lu-AuNP-c[RGDfK(C)], the MCF7 cell proliferation was significantly inhibited.
URI: http://ri.uaemex.mx/handle20.500.11799/39321
Other Identifiers: http://hdl.handle.net/20.500.11799/39321
Rights: info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0
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