Please use this identifier to cite or link to this item:
http://ri.uaemex.mx/handle20.500.11799/39412| DC Field | Value | Language |
|---|---|---|
| dc.creator | Fred Alonso López Durán | - |
| dc.creator | MARTHA PEDRAZA LOPEZ | - |
| dc.creator | CONSUELO ARTEAGA PEREZ | - |
| dc.creator | DIANA EDITH HERNANDEZ HERNANDEZ | - |
| dc.creator | ROCIO ANGELES GARCIA BECERRA | - |
| dc.creator | DAVID ORDAZ ROSADO | - |
| dc.date | 2009 | - |
| dc.date.accessioned | 2022-04-21T05:12:09Z | - |
| dc.date.available | 2022-04-21T05:12:09Z | - |
| dc.identifier | http://hdl.handle.net/20.500.11799/39412 | - |
| dc.identifier.uri | http://ri.uaemex.mx/handle20.500.11799/39412 | - |
| dc.description | The multistep process of angiogenesis offers several targets for therapeutic interventions. One molecular target structure is the alfa five beta three (av b3 ) integrin which is expressed on vascular endothelial cells and over-expressed in cancer tumor angiogenesis. To image neoangiogenesis in athymic mice with induced pancreatic, breast and prostate malignant tumors a new radiopharmaceutical was developed. The 99mTc-EDDA/HYNIC-cyclic-Arg-Gly- Asp-D-Phe-Lys (99mTc-cRGD) targets integrin receptors av b3 and was prepared with an average radiochemical purity > 95 %. 99mTc-cRGD shows high in vivo stability, fast blood clearance and rapid renal excretion in mice. There are statistical differences between tumor/muscle ratios for the 3 tumors studied. The highest tumor/non-target ratio was found in breast cancer (7.2 after 24 h) and a representative dorsal SPECT image was obtained where the tumor showed up very clearly over the background tissue. The high resolution of the image implies that 99mTc-cRGD will be of great value in nuclear medicine as a potential radiopharmaceutical for av b3 integrins receptor uptake and for imaging neoangiogenesis in neoplastic tissue and to follow up cancer tumor progression. | - |
| dc.format | application/application/pdf | - |
| dc.language | eng | - |
| dc.publisher | Asociación Mexicana de Bioquímica Clínica, A.C. | - |
| dc.relation | http://www.redalyc.org/revista.oa?id=576 | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0 | - |
| dc.source | Bioquimia (México) Num.2 Vol.34 | - |
| dc.subject | Química | - |
| dc.subject | Integrin av b3 | - |
| dc.subject | molecular imaging | - |
| dc.subject | angiogenesis | - |
| dc.subject | info:eu-repo/classification/cti/2 | - |
| dc.title | Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice | - |
| dc.type | article | - |
| dc.audience | students | - |
| dc.audience | researchers | - |
| item.grantfulltext | none | - |
| item.fulltext | No Fulltext | - |
| Appears in Collections: | Producción | |
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