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Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/67424
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dc.contributor.authorABRAHAM GONZALEZ RUIZen_EU
dc.contributor.authorGUILLERMINA FERRO FLORESen_EU
dc.contributor.authorERIKA PATRICIA AZORIN VEGAen_EU
dc.contributor.authorBLANCA ELI OCAMPO GARCIAen_EU
dc.contributor.authorFLOR DE MARIA RAMIREZ DE LA CRUZen_EU
dc.contributor.authorCLARA LETICIA SANTOS CUEVASen_EU
dc.contributor.authorLuis De León Rodríguezen_EU
dc.contributor.authorKEILA ISAAC OLIVEen_EU
dc.contributor.authorMYRNA ALEJANDRA LUNA GUTIERREZen_EU
dc.contributor.authorENRIQUE MORALES AVILAen_EU
dc.creatorABRAHAM GONZALEZ RUIZ-
dc.creatorGUILLERMINA FERRO FLORES-
dc.creatorERIKA PATRICIA AZORIN VEGA-
dc.creatorBLANCA ELI OCAMPO GARCIA-
dc.creatorFLOR DE MARIA RAMIREZ DE LA CRUZ-
dc.creatorCLARA LETICIA SANTOS CUEVAS-
dc.creatorLuis De León Rodríguez-
dc.creatorKEILA ISAAC OLIVE-
dc.creatorMYRNA ALEJANDRA LUNA GUTIERREZ-
dc.creatorENRIQUE MORALES AVILA-
dc.date2017-09-08-
dc.identifierhttp://hdl.handle.net/20.500.11799/67424-
dc.descriptionThe aim of this research was to synthesize and chemically characterize a cancer-specific 177Lu-Aunanoradiopharmaceutical based on gold nanoparticles (NPs), the nuclear localization sequence (NLS)-Arg-Gly- Asp peptide and an aptamer (HS-pentyl-pegaptanib) to target both the a(v)b(3) integrin and the vascular endothelial growth factor (VEGF) overexpressed in the tumor neovasculature, as well as to evaluate by the tube formation assay, the nanosystem capability to inhibit angiogenesis. 177Lu-NP-RGD-NLS-Aptamer was obtained with a radiochemical purity of 99 ± 1%. Complete inhibition of tube formation (angiogenesis) was demonstrated when endothelial cells (EA.hy926), cultured in a 3D-extracellular matrix support, were treated with the developed nanosystem.-
dc.descriptionMexican National Council of Science and Technology (CONACYT-SEP-CB-2014-01-242443).-
dc.languageeng-
dc.publisherSPRINGER Netherlands-
dc.relationdoi;10.1007/s10967-017-5465-x-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.source1588-2780-
dc.source0236-5731-
dc.subjectLutetium-177-
dc.subject177Lu-gold nanoparticles-
dc.subjectAntiangiogenic agent-
dc.subjectHS-pentyl-pegaptanib-
dc.subjectVEGF inhibition-
dc.subjectinfo:eu-repo/classification/cti/2-
dc.titleSynthesis and in vitro evaluation of an antiangiogenic cancerspecific dual-targeting 177Lu-Au-nanoradiopharmaceutical-
dc.typearticle-
dc.audiencestudents-
dc.audienceresearchers-
item.fulltextNo Fulltext-
item.grantfulltextnone-
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