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Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/79843
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dc.contributor.authorJOSE MARIA ELOY CONTRERAS ORTIZen_EU
dc.contributor.authorALBERTO BARBABOSA PLIEGOen_EU
dc.contributor.authorRIGOBERTO OROS PANTOJAen_EU
dc.contributor.authorJosé Esteban Aparicio Burgosen_EU
dc.contributor.authorJOSE ANTONIO ZEPEDA ESCOBARen_EU
dc.contributor.authorWAEL HEGAZY HASSAN MOUSTAFAen_EU
dc.contributor.authorLAUCEL OCHOA GARCIAen_EU
dc.contributor.authorMARIA UXUA ALONSO FRESANen_EU
dc.contributor.authorESVIETA TENORIO BORROTOen_EU
dc.contributor.authorJUAN CARLOS VAZQUEZ CHAGOYANen_EU
dc.creatorJOSE MARIA ELOY CONTRERAS ORTIZ-
dc.creatorALBERTO BARBABOSA PLIEGO-
dc.creatorRIGOBERTO OROS PANTOJA-
dc.creatorJosé Esteban Aparicio Burgos-
dc.creatorJOSE ANTONIO ZEPEDA ESCOBAR-
dc.creatorWAEL HEGAZY HASSAN MOUSTAFA-
dc.creatorLAUCEL OCHOA GARCIA-
dc.creatorMARIA UXUA ALONSO FRESAN-
dc.creatorESVIETA TENORIO BORROTO-
dc.creatorJUAN CARLOS VAZQUEZ CHAGOYAN-
dc.date2017-05-31-
dc.identifierhttp://hdl.handle.net/20.500.11799/79843-
dc.descriptionDuring Trypanosoma cruzi infection, oxidative stress is considered a contributing factor for dilated cardiomyopathy development. In this study, the effects of astaxanthin (ASTX) were evaluated as an alternative drug treatment for Chagas disease in a mouse model during the acute infection phase, given its anti-inflammatory, immunomodulating, and anti-oxidative properties. ASTX was tested in vitro in parasites grown axenically and in co-culture with Vero cells. In vivo tests were performed in BALB/c mice (4–6 weeks old) infected with Trypanosoma cruzi and supplemented with ASTX (10 mg/kg/day) and/or nifurtimox (NFMX; 100 mg/kg/day). Results show that ASTX has some detrimental effects on axenically cultured parasites, but not when cultured with mammalian cell monolayers. In vivo, ASTX did not have any therapeutic value against acute Trypanosoma cruzi infection, used either alone or in combination with NFMX. Infected animals treated with NFMX or ASTX/NFMX survived the experimental period (60 days), while infected animals treated only with ASTX died before day 30 post-infection. ASTX did not show any effect on the control of parasitemia; however, it was associated with an increment in focal heart lymphoplasmacytic infiltration, a reduced number of amastigote nests in cardiac tissue, and less hyperplasic spleen follicles when compared to control groups. Unexpectedly, ASTX showed a negative effect in infected animals co-treated with NFMX. An increment in parasitemia duration was observed, possibly due to ASTX blocking of free radicals, an antiparasitic mechanism of NFMX. In conclusion, astaxanthin is not recommended during the acute phase of Chagas disease, either alone or in combination with nifurtimox.-
dc.descriptionCONACYT PROY NO. 000000000156701. (REGISTRO INTERNO UAEM 3326)-
dc.languageeng-
dc.publisherEDP SCIENCES-
dc.relation24;17-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.source1776-1042-
dc.subjectastaxantina-
dc.subjecttrypanosoma cruzi-
dc.subjectchagas disease-
dc.subjectoxidative stress-
dc.subjectnifurtimox-
dc.subjectinfo:eu-repo/classification/cti/3-
dc.titleEffects of astaxanthin in mice acutely infected with Trypanosoma cruzi-
dc.typearticle-
dc.audiencestudents-
dc.audienceresearchers-
item.fulltextNo Fulltext-
item.grantfulltextnone-
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