1. DSpace-CRIS UAEMEX
  2. Interoperabilidad Repositorio Nacional
  3. Producción
Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/94975
DC FieldValueLanguage
dc.creatorMelissa Faria-
dc.creatorTamar Ziv-
dc.creatorCristian Gómez-Canela-
dc.creatorSHANI BEN LULU-
dc.creatorEva Prats-
dc.creatorKAREN ADRIANA NOVOA LUNA-
dc.creatorArie Admon-
dc.creatorBenjamin Piña-
dc.creatorRoma Tauler-
dc.creatorLeobardo Manuel Gómez Olivan-
dc.creatorDemetrio Raldua-
dc.date2018-05-21-
dc.date.accessioned2022-04-21T05:18:29Z-
dc.date.available2022-04-21T05:18:29Z-
dc.identifierhttp://hdl.handle.net/20.500.11799/94975-
dc.identifier.urihttp://ri.uaemex.mx/handle20.500.11799/94975-
dc.descriptionUn articulo indexado-
dc.descriptionAcute exposure to acrylamide (ACR), a type-2 alkene, may lead to a ataxia, skeletal muscles weakness and numbness of the extremities in human and laboratory animals. In the present manuscript, ACR acute neurotoxicity has been characterized in adult zebrafish, a vertebrate model increasingly used in human neuropharmacology and toxicology research. At behavioral level, ACR-treated animals exhibited “depression-like” phenotype comorbid with anxiety behavior. At transcriptional level, ACR induced down-regulation of regeneration-associated genes and up-regulation of oligodendrocytes and reactive astrocytes markers, altering also the expression of genes involved in the presynaptic vesicle cycling. ACR induced also significant changes in zebrafish brain proteome and formed adducts with selected cysteine residues of specific proteins, some of them essential for the presynaptic function. Finally, the metabolomics analysis shows a depletion in the monoamine neurotransmitters, consistent with the comorbid depression and anxiety disorder, in the brain of the exposed fish.-
dc.descriptionConacyt-
dc.languageeng-
dc.publisherScientific REPORTs-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.source2045-2322-
dc.subjectacrylamide-
dc.subjectzebra fish-
dc.subjectbehavior-
dc.subjectinfo:eu-repo/classification/cti/2-
dc.titleAcrylamide acute neurotoxicity in adult zebrafish-
dc.typearticle-
dc.audiencestudents-
dc.audienceresearchers-
item.grantfulltextnone-
item.fulltextNo Fulltext-
Appears in Collections:Producción
Show simple item record

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.