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Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/97057
DC FieldValueLanguage
dc.creatorEDUARDO PLATA VARGAS-
dc.creatorCinthia Yareli De la Cruz Hernández-
dc.creatorALEJANDRO DORAZCO GONZALEZ-
dc.creatorINES FUENTES NORIEGA-
dc.creatorDAVID MORALES MORALES-
dc.creatorJUAN MANUEL GERMAN ACACIO-
dc.date2017-
dc.date.accessioned2022-04-21T06:00:47Z-
dc.date.available2022-04-21T06:00:47Z-
dc.identifierhttp://hdl.handle.net/20.500.11799/97057-
dc.identifier.urihttp://ri.uaemex.mx/handle20.500.11799/97057-
dc.descriptionThe reaction by melt mixing at 220 °C of the antihypergly-cemic drug metformin hydrochloride1with dehydrated sodium suc-cinate yields efficiently the organic salt [MET]2[SUC]2(H-MET+=metforminium and SUC2-= succinate). Solid state CPMAS NMR13Cspectroscopy experiments, powder X-ray diffraction and FT-IR re-sults support the formation of the pharmaceutical salt2in goodyields. Besides, thecharged-assisted hydrogen bonding interactionsof type N-H...-O(carboxylate) were thoroughly analyzed by singlecrystal X-Ray diffraction techniques. Thus, the pharmaceutical salt2possesses considerable thermal differences when compared to thepure starting reagents. In addition, intrinsic dissolution rate expe-riments in buffered aqueous solutions at pH= 6.8 showed a sus-tained-release behavior of the drug in2with a constant value ofKint= 0.885 mg/min * cm2.-
dc.formatapplication/application/pdf-
dc.languageeng-
dc.publisherSociedad Química de México-
dc.relationhttp://www.redalyc.org/revista.oa?id=475-
dc.rightsinfo:eu-repo/semantics/Journal of the Mexican Chemical Society-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.sourceJournal of the Mexican Chemical Society (México) Num.3 Vol.61-
dc.subjectQuímica-
dc.subjectDiabetes-
dc.subjectMetformin-
dc.subjectX-ray structures-
dc.subjectssCPMAS NMR13C-
dc.subjectMelting-
dc.subjectSuccinate-
dc.subjectmechanochemistry-
dc.subjectgreen chemistry-
dc.subjectQuímica-
dc.subjectDiabetes-
dc.subjectMetformin-
dc.subjectX-ray structures-
dc.subjectssCPMAS NMR13C-
dc.subjectMelting-
dc.subjectSuccinate-
dc.subjectmechanochemistry-
dc.subjectgreen chemistry-
dc.subjectinfo:eu-repo/classification/cti/2-
dc.titleSynthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties-
dc.titleSynthesis of Metforminium Succinate by Melting. Crystal Structure, Thermal, Spectroscopic and Dissolution Properties-
dc.typearticle-
dc.audiencestudents-
dc.audienceresearchers-
item.grantfulltextnone-
item.fulltextNo Fulltext-
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