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Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/98963
DC FieldValueLanguage
dc.creatorMaría de los Ángeles Martínez Martínez-
dc.creatorHugo Mendieta Zerón-
dc.creatorLuis Gustavo Celis-
dc.creatorCRISTIAN FABIAN LAYTON TOVAR-
dc.creatorROCIO TORRES GARCIA-
dc.creatorLAURA ELISA GUTIERREZ PLIEGO-
dc.creatorENEIDA DEL SOCORRO CAMARILLO ROMERO-
dc.creatorJOSE DE JESUS GARDUÑO GARCIA-
dc.creatorMaría del Socorro Camarillo Romero-
dc.date2018-12-01-
dc.date.accessioned2019-05-01T06:01:00Z-
dc.date.available2019-05-01T06:01:00Z-
dc.identifierhttp://hdl.handle.net/20.500.11799/98963-
dc.identifier.urihttp://ri.uaemex.mx/handle20.500.11799/98963-
dc.descriptionSe analiza la expresión de polimorfismos en adolescentes y su asociación con parámetros del síndrome metabólico.-
dc.descriptionObjectives: This study aimed to describe correlations between glucose, insulin and adipokine levels and the homeostasis model assessment (HOMA) index with regards to the presence/absence of fat mass and obesity associated (FTO) rs9939609 and peroxisome proliferator-activated receptor (PPAR)-y rs1801282 single nucleotide polymorphisms (SNPs) as indicators of body mass index in adolescents. Methods: This cross-sectional study was conducted between September and December 2016 in Toluca, Mexico. A total of 71 students between 14–18 years old were included. Various anthropometric and laboratory measurements were collected, including lipid profile, glucose, insulin and adipokine levels and HOMA index. The degree of association between variables was evaluated with regards to the presence/absence of the SNPs. Results: Leptin levels were significantly higher among female students (P = 0.001), although adiponectin levels did not differ significantly (P = 0.060). There were significant positive correlations between insulin levels and HOMA index with FTO (r = 0.391; P = 0.007 and r = 0.413; P = 0.005, respectively) and PPARγ (r = 0.529; P = 0.007 and r = 0.537; P = 0.007, respectively) SNPs. Leptin showed a significant positive correlation in the presence of PPARγ (r = 0.483; P = 0.007) or in the absence of both SNPs (r = 0.627; P = 0.039). However, adiponectin was significantly negatively correlated in the presence of FTO, either alone (r = −0.333; P = 0.024) or in combination with PPARγ (r = −0.616; P = 0.043). Conclusion: The presence of FTO and/or PPARγ SNPs might be related to a genetic predisposition to metabolic syndrome.-
dc.descriptionThis study was funded with the aid of a grant from the Mexican Ministry of Education (grant #PROMEP/2013/CA-186/103105/13/9057).-
dc.languageeng-
dc.publisherSultan Qaboos University Med J-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.source2075-051X-
dc.subjecthomeostasis model assessment Index-
dc.subjectbody mass Index-
dc.subjectpolymorphisms-
dc.subjectadolescents-
dc.subjectinfo:eu-repo/classification/cti/3-
dc.titleCorrelation of the homeostasis model assessment Index and adiponectin, leptin and insulin levels to body mass index-associated gene polymorphisms in adolescents-
dc.typearticle-
dc.audiencestudents-
dc.audienceresearchers-
item.grantfulltextnone-
item.fulltextNo Fulltext-
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