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Title: | A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution | Keywords: | Cycloaddition reaction;tetrachloropyrimidines;1,3-diazadienes;intramolecular cyclization;nucleophilic substitution.;info:eu-repo/classification/cti/2 | Publisher: | Thieme | Description: | En el presente manuscrito se presenta un método nuevo para la preparación de tetracloropirimidinas y se presenta un estudio acerca de su reactividad química. A convenient two-step synthesis of 2-trichloromethyl-4-chloropyrimidines starting from 2-trichloromethyl-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared in one pot synthesis by a sequential acylation/intramolecular cyclization reaction between 2-trichloromethyl-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 2-trichloromethyl-4-chloropyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions. Conacyt |
URI: | http://ri.uaemex.mx/handle20.500.11799/99612 | Other Identifiers: | http://hdl.handle.net/20.500.11799/99612 | Rights: | info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 |
Appears in Collections: | Producción |
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