A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution

Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/99612

Title:	A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution
Keywords:	Cycloaddition reaction;tetrachloropyrimidines;1,3-diazadienes;intramolecular cyclization;nucleophilic substitution.;info:eu-repo/classification/cti/2
Publisher:	Thieme
Description:	En el presente manuscrito se presenta un método nuevo para la preparación de tetracloropirimidinas y se presenta un estudio acerca de su reactividad química. A convenient two-step synthesis of 2-trichloromethyl-4-chloropyrimidines starting from 2-trichloromethyl-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared in one pot synthesis by a sequential acylation/intramolecular cyclization reaction between 2-trichloromethyl-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 2-trichloromethyl-4-chloropyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions. Conacyt
URI:	http://ri.uaemex.mx/handle20.500.11799/99612
Other Identifiers:	http://hdl.handle.net/20.500.11799/99612
Rights:	info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0
Appears in Collections:	Producción

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