Synthesis of 5-substituted 2-pyrrolidinones by coupling of organozinc reagents with cyclic N-acyliminium ions

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Title:	Synthesis of 5-substituted 2-pyrrolidinones by coupling of organozinc reagents with cyclic N-acyliminium ions
Keywords:	Synthesis of 5-Substituted-2-pyrrolidinones by coupling of organozinc reagents with cyclic N-acyliminium ions;info:eu-repo/classification/cti/2
Publisher:	Thieme
Description:	En el presente trabajo se describe un procedimiento simple y fácil para la preparación de pirrolidinonas 5-sustituidas a partir de un acoplamiento entre iones N-aciliminio y reactivos organometálicos derivados de zinc A coupling reaction between cyclic N-acyliminium ions with organozinc reagents is described. The cyclic N-acyliminium ions, generated in situ from N-substituted-5-hydroxy-2-pyrrolidinones by treatment with BF3-etherate or titanium tetrachloride, were trapped by the organozinc reagent, formed by the alkylbromide in the presence of zinc in the same reaction media. The N-substituted 5-allyl-2-pyrrolidinones generated using this method, serves as versatile intermediates for the synthesis of azabicyclic systems with indolizidine and pyrroloazepinolizidine cores.
URI:	http://ri.uaemex.mx/handle20.500.11799/104783
Other Identifiers:	http://hdl.handle.net/20.500.11799/104783
Rights:	info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0
Appears in Collections:	Producción

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