Please use this identifier to cite or link to this item:
http://ri.uaemex.mx/handle20.500.11799/105026| DC Field | Value | Language |
|---|---|---|
| dc.creator | NALLELY PATRICIA JIMENEZ MANCILLA | - |
| dc.creator | KEILA ISAAC OLIVE | - |
| dc.creator | EUGENIO TORRES GARCIA | - |
| dc.creator | MIGUEL ANGEL CAMACHO LOPEZ | - |
| dc.creator | GERARDO JULIAN RAMIREZ NAVA | - |
| dc.creator | HECTOR JAVIER MENDOZA NAVA | - |
| dc.date | 2019-07-16 | - |
| dc.date.accessioned | 2022-04-21T06:01:49Z | - |
| dc.date.available | 2022-04-21T06:01:49Z | - |
| dc.identifier | http://hdl.handle.net/20.500.11799/105026 | - |
| dc.identifier.uri | http://ri.uaemex.mx/handle20.500.11799/105026 | - |
| dc.description | Cerenkov radiation (CR) is the emission of UV-vis light generated by the de-excitation of the molecules in the medium, after being polarized by an excited particle traveling faster than the speed of light. When β particles travel through tissue with energies greater than 219 keV, CR occurs. Tissues possess a spectral optical window of 600 to 1100 nm. The CR within this range can be useful for quantitative preclinical studies using optical imaging and for the in-vivo evaluation of 177Lu-radiopharmaceuticals (β-particle emitters). The objective of our research was to determine the experimental emission light spectrum of 177Lu-CR and evaluate its transmission properties in tissue as well as the feasibility to applying CR imaging in the preclinical studies of 177Lu-radiopharmaceuticals. The theoretical and experimental characterizations of the emission and transmission spectra of 177Lu-CR in tissue, in the vis-NIR region (350 to 900 nm), were performed using Monte Carlo simulation and UV-vis spectroscopy. Mice 177Lu-CR images were acquired using a charge-coupled detector camera and were quantitatively analyzed. The results demonstrated good agreement between the theoretical and the experimental 177Lu-CR emission spectra. Preclinical CR imaging demonstrated that the biokinetics of 177Lu-radiopharmaceuticals in the main organs of mice can be acquired | - |
| dc.description | This study was supported by the Mexican National Council of Science and Technology (CONACYT) through the CATEDRAS-CONACYT-ININ-337 and CONACYT-SEP-CB- 2016-286753 projects. It was carried out as part of the activities of the “Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos, CONACyT (LANIDER-CONACYT)” and the Red-Biofotónica, CONACYT. The financial support of the SIEA-UAEMex through the Grant No 4348/2017/CI is also acknowledged. | - |
| dc.language | eng | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0 | - |
| dc.source | 1083-3668 | - |
| dc.subject | Cerenkov radiation | - |
| dc.subject | 177Lu-radiopharmaceuticals | - |
| dc.subject | emission and light transmission in tissue | - |
| dc.subject | optical imaging | - |
| dc.subject | preclinical studies | - |
| dc.subject | info:eu-repo/classification/cti/2 | - |
| dc.title | Theoretical and experimental characterization of emission and transmission spectra of Cerenkov radiation generated by 177Lu in tissue | - |
| dc.type | article | - |
| dc.audience | students | - |
| dc.audience | researchers | - |
| item.grantfulltext | none | - |
| item.fulltext | No Fulltext | - |
| Appears in Collections: | Producción | |
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