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http://ri.uaemex.mx/handle20.500.11799/105026| Title: | Theoretical and experimental characterization of emission and transmission spectra of Cerenkov radiation generated by 177Lu in tissue | Keywords: | Cerenkov radiation;177Lu-radiopharmaceuticals;emission and light transmission in tissue;optical imaging;preclinical studies;info:eu-repo/classification/cti/2 | Description: | Cerenkov radiation (CR) is the emission of UV-vis light generated by the de-excitation of the molecules in the medium, after being polarized by an excited particle traveling faster than the speed of light. When β particles travel through tissue with energies greater than 219 keV, CR occurs. Tissues possess a spectral optical window of 600 to 1100 nm. The CR within this range can be useful for quantitative preclinical studies using optical imaging and for the in-vivo evaluation of 177Lu-radiopharmaceuticals (β-particle emitters). The objective of our research was to determine the experimental emission light spectrum of 177Lu-CR and evaluate its transmission properties in tissue as well as the feasibility to applying CR imaging in the preclinical studies of 177Lu-radiopharmaceuticals. The theoretical and experimental characterizations of the emission and transmission spectra of 177Lu-CR in tissue, in the vis-NIR region (350 to 900 nm), were performed using Monte Carlo simulation and UV-vis spectroscopy. Mice 177Lu-CR images were acquired using a charge-coupled detector camera and were quantitatively analyzed. The results demonstrated good agreement between the theoretical and the experimental 177Lu-CR emission spectra. Preclinical CR imaging demonstrated that the biokinetics of 177Lu-radiopharmaceuticals in the main organs of mice can be acquired This study was supported by the Mexican National Council of Science and Technology (CONACYT) through the CATEDRAS-CONACYT-ININ-337 and CONACYT-SEP-CB- 2016-286753 projects. It was carried out as part of the activities of the “Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos, CONACyT (LANIDER-CONACYT)” and the Red-Biofotónica, CONACYT. The financial support of the SIEA-UAEMex through the Grant No 4348/2017/CI is also acknowledged. |
URI: | http://ri.uaemex.mx/handle20.500.11799/105026 | Other Identifiers: | http://hdl.handle.net/20.500.11799/105026 | Rights: | info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 |
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