Please use this identifier to cite or link to this item:
http://ri.uaemex.mx/handle20.500.11799/39512| Title: | Coenzyme q10 microparticles formation with supercritical carbon dioxide | Keywords: | Ingeniería;Coenzyme Q10;bioavailability;micronization;supercritical carbon dioxide;info:eu-repo/classification/cti/7 | Publisher: | Universidad Autónoma Metropolitana Unidad Iztapalapa | Project: | http://www.redalyc.org/revista.oa?id=620 | Description: | Coenzyme Q10 is a powerful antioxidant used on cardiovascular, neurodegenerative and cancer diseases. Its hydrophobic nature do limit its applications, because human body absorbs it with dfculty, that is why it was proposed to increase its bioavailability by diminishing the particle size using supercritical carbon dioxide. It was determined experimentally the phase behavior of the coenzyme in a supercritical system. The equilibrium data and a factorial 2k experimental design were utilized to find how the shape and size of the microparticles are affected by temperature, coQ10 concentration and nozzle diameter. Microparticles were characterized using infrared spectrometry and chromatography. For verify the fundamental chemical structure, the size and the shape of the microparticles was used scanning electronic microscopy. It was found a significant decrease in particle size and a modification of physical structure. The antioxidant power of coQ10 after micronization was measured, showing an increase of this property. Finally, in order to evaluate the bioavailability, the kinetic of solubility was determined in ethanol, having a substantial increase on solubilization speed of micronized coQ10 compared with the commercial one. | URI: | http://ri.uaemex.mx/handle20.500.11799/39512 | Other Identifiers: | http://hdl.handle.net/20.500.11799/39512 | Rights: | info:eu-repo/semantics/Revista Mexicana de Ingeniería Química info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 |
| Appears in Collections: | Producción |
Show full item record
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.