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Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/79745
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dc.contributor.authorHECTOR JAVIER MENDOZA NAVAen_EU
dc.contributor.authorGUILLERMINA FERRO FLORESen_EU
dc.contributor.authorFLOR DE MARIA RAMIREZ DE LA CRUZen_EU
dc.contributor.authorBLANCA ELI OCAMPO GARCIAen_EU
dc.contributor.authorCLARA LETICIA SANTOS CUEVASen_EU
dc.contributor.authorERIKA PATRICIA AZORIN VEGAen_EU
dc.contributor.authorNALLELY PATRICIA JIMENEZ MANCILLAen_EU
dc.contributor.authorMYRNA ALEJANDRA LUNA GUTIERREZen_EU
dc.contributor.authorKEILA ISAAC OLIVEen_EU
dc.creatorHECTOR JAVIER MENDOZA NAVA-
dc.creatorGUILLERMINA FERRO FLORES-
dc.creatorFLOR DE MARIA RAMIREZ DE LA CRUZ-
dc.creatorBLANCA ELI OCAMPO GARCIA-
dc.creatorCLARA LETICIA SANTOS CUEVAS-
dc.creatorERIKA PATRICIA AZORIN VEGA-
dc.creatorNALLELY PATRICIA JIMENEZ MANCILLA-
dc.creatorMYRNA ALEJANDRA LUNA GUTIERREZ-
dc.creatorKEILA ISAAC OLIVE-
dc.date2017-05-04-
dc.date.accessioned2019-01-16T15:26:01Z-
dc.date.available2019-01-16T15:26:01Z-
dc.identifierhttp://hdl.handle.net/20.500.11799/79745-
dc.identifier.urihttp://ri.uaemex.mx/handle20.500.11799/79745-
dc.descriptionThe integration of fluorescence and plasmonic properties into one molecule is of importance in developing multifunctional imaging and therapy nanoprobes. The aim of this research was to evaluate the fluorescent properties and the plasmonic–photothermal, therapeutic, and radiotherapeutic potential of 177Lu–dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity (177Lu–DenAuNP–folate–bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP–folate–bombesin for optical imaging. After laser irradiation, the presence of the nanosystem in cells caused a significant increase in the temperature of the medium (46.8oC, compared to 39.1oC without DenAuNP–folate–bombesin, P < 0.05), resulting in a significant decrease in cell viability (down to 16.51% + 1.52%) due to the 177Lu–DenAuNP–folate–bombesin plasmonic properties. After treatment with 177Lu–DenAuNP–folate–bombesin, the T47D cell viability decreased 90% because of the radiation-absorbed dose (63.16 + 4.20 Gy) delivered inside the cells. The 177Lu–DenAuNP–folate–bombesin nanoprobe internalized in cancer cells exhibited properties suitable for optical imaging, plasmonic–photothermal therapy, and targeted radiotherapy.-
dc.descriptionCONACYT-SEP-CB-2014-01-242443-
dc.languageeng-
dc.publisherSAGE-
dc.relationDOI: 10.1177/1536012117704768;-
dc.relationVol.;16-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0-
dc.source15360121-
dc.subjectlutetium-177-
dc.subjectradiolabeled dendrimers-
dc.subjectradiolabeled nanoprobe-
dc.subjectmultifunctional radiopharmaceuticals-
dc.subjectheterobivalent molecules-
dc.subjectbreast cancer-
dc.subjectdendrimers-
dc.subjectgold nanoparticles-
dc.subjectinfo:eu-repo/classification/cti/3-
dc.titleFluorescent, Plasmonic, and Radiotherapeutic Properties of the 177Lu–Dendrimer-AuNP–Folate–Bombesin Nanoprobe Located Inside Cancer Cells-
dc.typearticle-
dc.audiencestudents-
dc.audienceresearchers-
item.fulltextNo Fulltext-
item.grantfulltextnone-
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