Please use this identifier to cite or link to this item: http://ri.uaemex.mx/handle20.500.11799/79748
Title: Preparation and in vitro evaluation of 177Lu-iPSMA-RGD as a new heterobivalent radiopharmaceutical
Authors: ALONDRA ESCUDERO CASTELLANOS 
BLANCA ELI OCAMPO GARCIA 
GUILLERMINA FERRO FLORES 
KEILA ISAAC OLIVE 
CLARA LETICIA SANTOS CUEVAS 
ANDREA GUADALUPE OLMOS ORTIZ 
JANICE GARCIA QUIROZ 
ROCIO ANGELES GARCIA BECERRA 
LORENZA DIAZ NIETO 
Keywords: PSMA inhibitor;RGD peptide;177Lu;177Lulabeled PSMA inhibitor;177Lu-labeled RGD;Heterobivalent radiopharmaceutical;info:eu-repo/classification/cti/3
Publisher: J Radioanal Nucl Chem
Project: DOI 10.1007/s10967-017-5555-9; 
Description: This study aimed to synthesize a new 177Lu-iPSMA-RGD heterobivalent radiopharmaceutical, as well as to assess the in vitro radiopharmaceutical potential to target cancer cells overexpressing PSMA and a(v) b(3) integrins. The radiotracer prepared with a radiochemical purity of 98.8 ± 1.0% showed stability in human serum, specific recognition with suitable affinity to PSMA and a(v)b(3) integrins, and capability to inhibit cancer cell proliferation and VEGF signaling (antiangiogenic effect). Results warrant further preclinical studies to establish the 177Lu-iPSMA-RGD potential as a dual therapeutic radiopharmaceutical.
CONACyT-CB-2016-01-281526
Other Identifiers: http://hdl.handle.net/20.500.11799/79748
Rights: info:eu-repo/semantics/embargoedAccess
http://creativecommons.org/licenses/by-nc-nd/4.0
Appears in Collections:Producción

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