Please use this identifier to cite or link to this item:
http://ri.uaemex.mx/handle20.500.11799/79748| DC Field | Value | Language |
|---|---|---|
| dc.creator | ALONDRA ESCUDERO CASTELLANOS | - |
| dc.creator | BLANCA ELI OCAMPO GARCIA | - |
| dc.creator | GUILLERMINA FERRO FLORES | - |
| dc.creator | KEILA ISAAC OLIVE | - |
| dc.creator | CLARA LETICIA SANTOS CUEVAS | - |
| dc.creator | ANDREA GUADALUPE OLMOS ORTIZ | - |
| dc.creator | JANICE GARCIA QUIROZ | - |
| dc.creator | ROCIO ANGELES GARCIA BECERRA | - |
| dc.creator | LORENZA DIAZ NIETO | - |
| dc.date | 2017-10-20 | - |
| dc.identifier | http://hdl.handle.net/20.500.11799/79748 | - |
| dc.description | This study aimed to synthesize a new 177Lu-iPSMA-RGD heterobivalent radiopharmaceutical, as well as to assess the in vitro radiopharmaceutical potential to target cancer cells overexpressing PSMA and a(v) b(3) integrins. The radiotracer prepared with a radiochemical purity of 98.8 ± 1.0% showed stability in human serum, specific recognition with suitable affinity to PSMA and a(v)b(3) integrins, and capability to inhibit cancer cell proliferation and VEGF signaling (antiangiogenic effect). Results warrant further preclinical studies to establish the 177Lu-iPSMA-RGD potential as a dual therapeutic radiopharmaceutical. | - |
| dc.description | CONACyT-CB-2016-01-281526 | - |
| dc.language | eng | - |
| dc.publisher | J Radioanal Nucl Chem | - |
| dc.relation | DOI 10.1007/s10967-017-5555-9; | - |
| dc.rights | info:eu-repo/semantics/openAccess | - |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/4.0 | - |
| dc.source | 0236-5731 | - |
| dc.subject | PSMA inhibitor | - |
| dc.subject | RGD peptide | - |
| dc.subject | 177Lu | - |
| dc.subject | 177Lulabeled PSMA inhibitor | - |
| dc.subject | 177Lu-labeled RGD | - |
| dc.subject | Heterobivalent radiopharmaceutical | - |
| dc.subject | info:eu-repo/classification/cti/3 | - |
| dc.title | Preparation and in vitro evaluation of 177Lu-iPSMA-RGD as a new heterobivalent radiopharmaceutical | - |
| dc.type | article | - |
| dc.audience | students | - |
| dc.audience | researchers | - |
| item.grantfulltext | none | - |
| item.fulltext | No Fulltext | - |
| Appears in Collections: | Producción | |
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