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http://ri.uaemex.mx/handle20.500.11799/79750| Title: | Study of the Optical Properties of Functionalized Gold Nanoparticles in Different Tissues and Their Correlation with the Temperature Increase | Authors: | ANDRES CARRILLO CAZARES NALLELY PATRICIA JIMENEZ MANCILLA MYRNA ALEJANDRA LUNA GUTIERREZ KEILA ISAAC OLIVE MIGUEL ANGEL CAMACHO LOPEZ |
Keywords: | gold nanoparticles;AuNP-RGD;thermotherapy;absorption coefficients;biological tissue;info:eu-repo/classification/cti/3 | Publisher: | Hindawi | Project: | https://doi.org/10.1155/2017/3628970; | Description: | Mie theory explains the interaction of light with a gold nanoparticle (AuNP) through the absorption (饾惗abs), scattering (饾惗sca), and extinction (饾惗ext) cross sections. These parameters have been calculated in the case of AuNPs dispersed in homogeneous media, but not for specific tissues. The aim of this research was to theoretically obtain the optical cross sections (饾惗abs, 饾惗sca, and 饾惗ext) of functionalized AuNPs in liver and colon tissues through Mie theory and correlate them with the temperature increase observed experimentally in tissues containing AuNPs under plasmonic photothermal irradiation using a Nd-YAG laser (饾渾 = 532 nm). Calculations showed that 饾惗abs represents 98.96 卤 0.03% of 饾惗ext at 532 nm. The 饾惗ext value for a functionalized AuNP in water was 365.66 nm2 (94% of the theoretical maximum value at 522.5 nm), 404.24 nm2 in colon (98% of the theoretical maximum value at 525 nm), and 442.39nm2 in liver (96% of the theoretical maximum value at 525 nm). Therefore, nanoparticles irradiated at 532nm are very close to their resonance value.These results correlated with the experimental irradiation of functionalized AuNPs in different tissues, where the average temperature increase showed the pattern liver > colon > water. The temperature increase observed (螖饾憞 up to 13鈭楥) is sufficient to produce cellular death. CATEDRAS-CONACYT-ININ-337 CONACYT-SEP-CB-2014-01-242443). |
URI: | http://ri.uaemex.mx/handle20.500.11799/79750 | Other Identifiers: | http://hdl.handle.net/20.500.11799/79750 | Rights: | info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 |
| Appears in Collections: | Producci贸n |
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