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http://ri.uaemex.mx/handle20.500.11799/96909| Title: | Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice |
Keywords: | Multidisciplinarias (Ciencias Sociales);Oxidative stress;lipid peroxidation;iron deficiency;central nervous system;spleen;Multidisciplinarias (Ciencias Sociales);Oxidative stress;lipid peroxidation;iron deficiency;central nervous system;spleen;info:eu-repo/classification/cti/5 | Publisher: | Universidad de Guanajuato | Project: | http://www.redalyc.org/revista.oa?id=416 | Description: | Oxidative stress (OS) is considered a risk factor for neurodegenerative disorders. Iron concentrations have been related to OS; however, the effect of iron deficiency (ID) on the induction of OS in the central nervous system (CNS) is unknown. A murine model of chronic diet-induced ID using 2 month-old male BALB/c mice (6 specimen), was used to determine its role in OS induction. Lipid peroxidation was determined by measuring thiobarbituric acid-reactive species (TBARS) in the CNS, using the spleen for comparison. A decrease of peroxidation products in the CNS of the ID group (ID CNS), compared to controls fed on a regular diet, was found. The spleen showed a significant increase of lipid peroxidation in the ID group. Our results suggest that chronic ID may have differential effects on OS in the CNS and peripheral tissues. A decreased amount of reactive oxygen species in the basal state may be related to alterations on normal CNS metabolism and functions under chronic ID. | URI: | http://ri.uaemex.mx/handle20.500.11799/96909 | Other Identifiers: | http://hdl.handle.net/20.500.11799/96909 | Rights: | info:eu-repo/semantics/Acta Universitaria info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0 |
| Appears in Collections: | Producción |
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