El diseño y síntesis de compuestos bioactivos asistido por la síntesis orgánica para su posterior evaluación biológica ha sido un continuo quehacer de la química medicinal. En este capítulo, los autores describen novedosos ...

The exploration of azide-enolate cycloaddition in the synthesis of novel Rufinamide analogs is reported for the first time. A very simple procedure involving the use of β-ketonitriles as dipolarophiles afforded 5-aril/heteroayl ...

The synthesis of novel of 4,5,6,7-tetrahydrobenzoxazol-2-ones is herein reported. They were obtained in moderate to good yields by a highly regio- and stereoselective Diels-Alder cycloaddition of N-substituted exo-oxazolidin-2-one ...