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In vitro and in vivo synergistic effect of radiotherapy and plasmonic photothermal therapy on the viability of cancer cells using 177Lu–Au-NLS-RGD-Aptamer nanoparticles under laser irradiation
This research aimed to evaluate the photothermal and radiotherapeutic effect of the 177Lu–Au-RGD-NLS-Aptamer antiangiogenic
nanosystem on the viability of U87MG cancer cells by using in vitro and in vivo models, as well as to assess the
synergic effect of both therapies. In vitro results demonstrated a decrease in cell viability to 2.14 ± 0.27% after the
treatment with photothermal therapy plus radiotherapy. These results correlated with the observed in vivo therapeutic
response in mice with U87MG-induced tumors, in which 177Lu–Au-RGD-NLS-Aptamer under laser irradiation inhibited
tumor progression. The combination of radiotherapy and thermotherapy in one nanoradiopharmaceutical could be
potentially useful for cancer treatment.
In vitro and in vivo synergistic effect of radiotherapy and plasmonic photothermal therapy on the viability of cancer cells using 177Lu–Au-NLS-RGD-Aptamer nanoparticles under laser irradiation
Autor
Gonzalez-Ruiz, Abraham
Ferro-Flores, Guillermina
Jimenez-Mancilla, Nallely
Escudero-Castellanos, Alondra
Ocampo-Garcıa, Blanca
Luna-Gutierrez, Myrna
Santos-Cuevas, Clara
Morales-Avila, Enrique
Isaac-Olive, Keila
Fecha de publicación
2018-11-03
Editor
Journal of Radioanalytical and Nuclear Chemistry
Tipo de documento
Artículo
Palabras clave
Lutetium-177
177Lu–gold nanoparticles
Plasmonic photothermal therapy
Anti-VEGF aptamer
RGD peptide
Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)