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| dc.contributor.author | Isaac-Olivé, Keila
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| dc.contributor.author | Ocampo-García, Blanca E.
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| dc.contributor.author | Aranda-Lara, Liliana
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| dc.contributor.author | Santos-Cuevas, Clara L.
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| dc.contributor.author | Jiménez-Mancilla, Nallely P.
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| dc.contributor.author | Luna-Gutiérrez, Myrna A.
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| dc.contributor.author | Medina, Luis. A.
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| dc.contributor.author | Nagarajan, Bhavani
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| dc.contributor.author | Sabnis, Nirupama
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| dc.contributor.author | Raut, Sangram
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| dc.contributor.author | Prokai, Laszlo
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| dc.contributor.author | Lacko, Andras G.
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| dc.date.accessioned | 2019-02-01T20:10:28Z | |
| dc.date.available | 2019-02-01T20:10:28Z | |
| dc.date.issued | 2019-01-07 | |
| dc.identifier.issn | 2040-3372 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11799/98788 | |
| dc.description.abstract | Despite the widespread use of nanotechnology in radio-imaging applications, lipoprotein based delivery systems have received only limited attention so far. These studies involve the synthesis of a novel hydrophobic radio-imaging tracer consisting of a hydrazinonicotinic acid (HYNIC)-N-dodecylamide and 99mTc conjugate that can be encapsulated into rHDL nanoparticles (NPs). These rHDL NPs can selectively target the Scavenger Receptor type B1 (SR-B1) that is overexpressed on most cancer cells due to excess demand for cholesterol for membrane biogenesis and thus can target tumors in vivo. We provide details of the tracer synthesis, characterization of the rHDL/tracer complex, in vitro uptake, stability studies and in vivo application of this new radio-imaging approach | es |
| dc.description.sponsorship | This work was supported by the Universidad Autónoma del Estado de México (UAEMex) and the University of North Texas Health Science Center (UNTHSC) through the joined “Seed- Grant” 3889/2015FS, Wheels for Wellness, Fort Worth, and the Robert A. Welch Foundation (endowment BK-0031 to L. P.). The authors thank Samantha M. Brewer and Professor Kayla N. Green (Texas Christian University, Fort Worth) for their help in the interpretation of the NMR spectra. This research was carried out as a part of the activities of the “Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos”, CONACYT-Mexico and it was also supported by the Research Sectoral Fund for Education SEP-CONACYT-Mexico through the grant number CB-2016-287217. This work was supported in part by grants from Leukemia Texas and Texas Alzheimer’s Research Care and Consortium (2018-48-51-JI) to Sangram Raut. | es |
| dc.language.iso | eng | es |
| dc.publisher | Nanoscale | es |
| dc.relation.ispartofseries | DOI;10.1039/c8nr07484d | |
| dc.rights | embargoedAccess | es |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es |
| dc.rights | embargoedAccess | es |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/ | es |
| dc.subject | nanoparticles | es |
| dc.subject | high density lipoproteins | es |
| dc.subject | 99mTc-HDL | es |
| dc.subject | 99mTc-HYNIC-DA | es |
| dc.subject | SRB1 receptor | es |
| dc.title | [99mTc-HYNIC-N-dodecylamide]: a new hydrophobic tracer for labelling reconstituted highdensity lipoproteins (rHDL) for radioimaging | es |
| dc.type | Artículo | es |
| dc.provenance | Científica | es |
| dc.road | Dorada | es |
| dc.ambito | Internacional | es |
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