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dc.contributor.author Pérez Mancilla, Nallely P
dc.contributor.author Isaac Olivé, Keila
dc.contributor.author Torres García, Eugenio
dc.contributor.author Camacho López, Miguel Ángel
dc.contributor.author Ramírez Nava, Gerardo Julián
dc.contributor.author Mendoza Nava, Héctor Javier
dc.date.accessioned 2019-11-14T23:11:17Z
dc.date.available 2019-11-14T23:11:17Z
dc.date.issued 2019-07-16
dc.identifier.issn 1083-3668
dc.identifier.uri http://hdl.handle.net/20.500.11799/105026
dc.description.abstract Cerenkov radiation (CR) is the emission of UV-vis light generated by the de-excitation of the molecules in the medium, after being polarized by an excited particle traveling faster than the speed of light. When β particles travel through tissue with energies greater than 219 keV, CR occurs. Tissues possess a spectral optical window of 600 to 1100 nm. The CR within this range can be useful for quantitative preclinical studies using optical imaging and for the in-vivo evaluation of 177Lu-radiopharmaceuticals (β-particle emitters). The objective of our research was to determine the experimental emission light spectrum of 177Lu-CR and evaluate its transmission properties in tissue as well as the feasibility to applying CR imaging in the preclinical studies of 177Lu-radiopharmaceuticals. The theoretical and experimental characterizations of the emission and transmission spectra of 177Lu-CR in tissue, in the vis-NIR region (350 to 900 nm), were performed using Monte Carlo simulation and UV-vis spectroscopy. Mice 177Lu-CR images were acquired using a charge-coupled detector camera and were quantitatively analyzed. The results demonstrated good agreement between the theoretical and the experimental 177Lu-CR emission spectra. Preclinical CR imaging demonstrated that the biokinetics of 177Lu-radiopharmaceuticals in the main organs of mice can be acquired es
dc.description.sponsorship This study was supported by the Mexican National Council of Science and Technology (CONACYT) through the CATEDRAS-CONACYT-ININ-337 and CONACYT-SEP-CB- 2016-286753 projects. It was carried out as part of the activities of the “Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos, CONACyT (LANIDER-CONACYT)” and the Red-Biofotónica, CONACYT. The financial support of the SIEA-UAEMex through the Grant No 4348/2017/CI is also acknowledged. es
dc.language.iso eng es
dc.rights openAccess es
dc.rights https://creativecommons.org/licenses/by-nc-nd/4.0/ es
dc.rights openAccess es
dc.rights https://creativecommons.org/licenses/by-nc-nd/4.0/ es
dc.subject Cerenkov radiation es
dc.subject 177Lu-radiopharmaceuticals es
dc.subject emission and light transmission in tissue es
dc.subject optical imaging es
dc.subject preclinical studies es
dc.title Theoretical and experimental characterization of emission and transmission spectra of Cerenkov radiation generated by 177Lu in tissue es
dc.type Artículo es
dc.provenance Científica es
dc.road Dorada es
dc.ambito Internacional es
dc.modalidad Artículo especializado para publicar en revista indizada es


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  • Título
  • Theoretical and experimental characterization of emission and transmission spectra of Cerenkov radiation generated by 177Lu in tissue
  • Autor
  • Pérez Mancilla, Nallely P
  • Isaac Olivé, Keila
  • Torres García, Eugenio
  • Camacho López, Miguel Ángel
  • Ramírez Nava, Gerardo Julián
  • Mendoza Nava, Héctor Javier
  • Fecha de publicación
  • 2019-07-16
  • Tipo de documento
  • Artículo
  • Palabras clave
  • Cerenkov radiation
  • 177Lu-radiopharmaceuticals
  • emission and light transmission in tissue
  • optical imaging
  • preclinical studies
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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