LAS REDES METAL ORGÁNICAS (MOF) COMO PLATAFORMAS DE INCLUSIÓN Y LIBERACIÓN DE BIOMOLÉCULAS Y SUS APLICACIONES.

Abstract

Metal Organic Frameworks (MOFs) are a class of crystalline materials that, thanks to their large surface area and high porosity, allow them to be used in various areas of knowledge. This diversity of applications is due to the metal ions and the organic binders that compose them, but it is also important to highlight the ability of MOFs to function as hosts for a great variety of molecules of very different sizes and chemical properties. This work is basically divided into two parts: the first part consists of the work carried out within the first two semesters of the Postgraduate program, which covers the synthesis of BioMOFN through its structural units: zinc (Zn), adenine (Ad) and Benzyl-Tricarboxylic acid (BTC). The second part includes the online work carried out in the two remaining semesters (after the closure of the laboratories due to the health emergency of the COVID-19 disease), this part consists of the documentary research to develop a review article about incorporation of biomolecules in MOFs and their applications. Part one experimentally supports a way in which small biomolecules like adenine function as units to build new MOFs, with new properties. Part two provides a documentary basis for the work where the other existing approaches for incorporating biomolecules in MOFs are discussed; pore encapsulation, surface bonding, covalent bonding, in situ encapsulation.