Deiodinase 1 serum levels in the second trimester of pregnancy

Abstract

Thyroid disease is one of the most frequent causes of gestational endocrinopathies. Deiodinases play an important role controlling the concentration of thyroid hormones at the tissue level and the homeostasis of thyroid hormones, on pregnant women; specifically, Deiodinase type 1 (D1) may control the TSH levels. To determine the serum levels of D1 in Mexican pregnant women who are in the second trimester of pregnancy. A prospective, descriptive, and cross-sectional study was carried out with a sample of 52 patients in their second trimester of pregnancy who attended the outpatient clinic of the "Mónica Pretelini Sáenz'' Maternal Perinatal Hospital (HMPMPS), in Toluca, Mexico. A peripheral blood sample was taken to quantify the values of D1 and TSH. The Spearman rank correlation coefficient test using SPSS statistics version 21 software was tested between these two variables. D1 mean value was of 491.3 pg / mL (± 340.48), TSH mean value was 5.25 mIU / mL (± 3.34), and rs = 0.023 (p = 0.869) was found. Discussion: Based on the study result, the use of D1 quantification to observe changes in maternal TSH has a non-significant weak positive correlation, restricting its usefulness for timely diagnosis of thyroid abnormalities during pregnancy. The use of D1 quantification during the second trimester of pregnancy did not show significance to determine thyroid alterations in relation to TSH values in the Mexican population.