Listar Científica por autor "90af6596-fdcb-4bd0-ae1c-089f39ebe933"

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A review of antiepileptic drugs: Part 1 Occurrence, fate in aquatic environments and removal during different treatment technologies.

Cardo Vera, Jesús Daniel; Elizalde Velázquez, Gustavo Axel; Islas Flores, Hariz; Mejía García, Alejandro; Ortega Olvera, José Mario; Gómez Oliván, Leobardo Manuel (Science of the Total Environment, 2021-01-30)

Antiepileptic drugs (AEDs) are the main treatment for people with epilepsy. However, in recent years, more and more people are using them for other indications such as: migraine, chronic neuropathic pain, and mood disorders. ...
Acute exposure to 17--ethinylestradiol disrupt the embryonic development and oxidative status of Danio rerio

Ramírez Montero, María del Carmen; Gómez Oliván, Leobardo Manuel; Gutiérrez Noya, Verónica Margarita; Orozco Hernández, Jose Manuel; Islas Flores, Hariz; Elizalde Velázquez, Gustavo Axel; San Juan Reyes, Nely; Galar Martínez, Marcela (Comparative Biochemistry and Physiology, Part C, 2021-10-02)

17-Alpha-ethinylestradiol (EE2) is an estrogen derived from estradiol (E2). This compound and is one of the most widely used drugs both in humans and animals. Numerous studies have reported the ability of EE2 to alter sex ...
Acute exposure to environmentally relevant concentrations of phenytoin damages early development and induces oxidative stress in zebrafish embryos.

Cardoso-Vera, Jesús Daniel; Gómez-Oliván, Leobardo Manuel; Islas-Flores, Hariz; García-Medina, Sandra; Orozco-Hernández, José Manuel; Heredia-García, Gerardo; Elizalde-Velázquez, Gustavo Axel; Galar-Martínez, Marcela; SanJuan-Reyes, Nely (Martin Grosell, 2022-01-03)

Phenytoin (PHE) is an antiepileptic drug that has been widely used in clinical practice for about 80 years. It is mainly used in the treatment of tonic-clonic and partial seizures. The widespread consumption of this drug ...
Acute exposure to environmentally relevant concentrations of sucralose disrupts embryonic development and leads to an oxidative stress response in Danio rerio.

Colín García, Karla; Elizalde Velázquez, Gustavo Axel; Gómez Oliván, Leobardo Manuel; Islas Flores, Hariz; García Medina, Sandra; Galar Martínez, Marcela (Science of the Total Environment, 2022-03-18)

Sucralose (SUC) is the most consumed artificial sweetener worldwide, not metabolized by the human body, and barely eliminated from water in wastewater treatment plants. Although different studies have reported high ...
Acute exposure to realistic concentrations of Bisphenol-A trigger health damage in fish: Blood parameters, gene expression, oxidative stress.

Elizalde-Velázquez, Gustavo Axel; Gómez-Oliván, Leobardo Manuel; Herrera-Vázquez, Selene Elizabeth; Rosales-Pérez, Karina Elisa; SanJuan-Reyes, Nely; García-Medina, Sandra; Galar-Martínez, Marcela (2023-06-11)

Despite much information regarding BPA toxicity in fish and other aquatic organisms, data is still misleading as most studies have utilized concentrations several orders of magnitude higher than those typically found in ...
Antidiabetic drug metformin disrupts the embryogenesis in zebrafish through an oxidative stress mechanism

Elizalde Velázquez, Gustavo Axel; Gómez Oliván, Leobardo Manuel; García Medina, Sandra; Islas Flores, Hariz; Hernández Navarro, María Dolores; Galar Martínez, Marcela (Chemosphere, 2021-07-07)

In recent years, the consumption of metformin has increased not only due to the higher prevalence of type 2 diabetes, but also due to their usage for other indications such as cancer and polycystic ovary syndrome. Consequently, ...
Brain damage induced by contaminants released in a hospital from Mexico: Evaluation of swimming behavior, oxidative stress, and acetylcholinesterase in zebrafish (Danio rerio)

Rosales-Pérez, Karina Elisa; Elizalde-Velázquez, Gustavo Axel; Gómez-Oliván, Leobardo Manuel; Orozco-Hernández, José Manuel; Cardoso-Vera, Jesús Daniel; Heredia-García, Gerardo; Islas-Flores, Hariz; García-Medina, Sandra; Galar-Martínez, Marcela (James Lazorchak, 2022-01-29)

Several studies have indicated that hospital effluents can produce genotoxic and mutagenic effects, cytotoxicity, hematological and histological alterations, embryotoxicity, and oxidative stress in diverse water organisms, ...
Chronic exposure to environmentally relevant concentrations of guanylurea induces neurotoxicity of Danio rerio adults

Elizalde-Velázquez, Gustavo Axel; Gómez-Oliván, Leobardo Manuel; Rosales-Pérez, Karina Elisa; Orozco-Hernández, José Manuel; García-Medina, Sandra; Islas-Flores, Hariz; Galar-Martínez, Marcela (Damia Barcelo, 2022-01-14)

Recent studies have shown guanylurea (GUA) alters the growth and development of fish, induces oxidative stress, and disrupts the levels and expression of several genes, metabolites, and proteins related to the overall ...
Chronic exposure to realistic concentrations of metformin prompts a neurotoxic response in Danio rerio adults

Elizalde Velázquez, Gustavo Axel; Gómez-Oliván, Leobardo Manuel; García-Medina, Sandra; Rosales-Pérez, Karina Elisa; Orozco-Hernández, José Manuel; Islas-Flores, Hariz; Galar-Martínez, Marcela; Hernández-Navarro, María Dolores (Science of the Total Environment, 2022-08-09)

Metformin (MET) is among the most consumed drugs around the world, and thus, it is considered the uppermost drug in mass discharged into water settings. Nonetheless, data about the deleterious consequences of MET on water ...
Chronic intake of an enriched diet with spirulina (Arthrospira maxima) alleviates the embryotoxic effects produced by realistic concentrations of tetracycline in Danio rerio

Tenorio-Chávez, Paulina; Elizalde-Velázquez, Gustavo Axel; Gómez-Oliván, Leobardo Manuel; Hernández-Navarro, María Dolores (Science of the Total Environment, 2022-11-08)

Tetracycline (TC) is one of the most consumed antibiotics worldwide. Due to its high consumption, recent studies have reported its presence in aquatic environments and have assessed its effects on fish, algae, and daphniids. ...
Effects of oxidative stress induced by environmental relevant concentrations of fluoxetine on the embryonic development on Danio rerio

Orozco-Hernández, José Manuel; Gómez-Oliván, Leobardo Manuel; Elizalde-Velázquez, Gustavo Axel; Heredia-García, Gerardo; Cardoso-Vera, Jesús Daniel; Dublan-García, Octavio; Islas-Flores, Hariz; SanJuan- Reyes, Nely; Galar-Martínez, Marcela (Damiá Barceló, 2021-10-18)

Fluoxetine (FLX) is a psychoactive drug that acts as an antidepressant. FLX is one of the world's best-selling pre- scription antidepressants. FLX is widely used for the treatment of various psychiatric disorders. For these ...
Embriotoxicidad y teratogenicidad inducida por metformina y guanylurea en embriones de Danio rerio

Elizalde Velázquez, Gustavo Axel (2021-09-03)

En los últimos años, el consumo de metformina (MET) ha aumentado no solo por la mayor prevalencia de diabetes tipo 2, sino también por su uso para otras indicaciones como el cáncer y el síndrome de ovario poli quístico. ...
Fluoxetine-induced neurotoxicity at environmentally relevant concentrations in adult zebrafish Danio rerio.

Orozco-Hernández, José Manuel; Gómez Oliván, Leobardo Manuel; Elizalde Velázquez, Gustavo Axel; Rosales Pérez, Karina Elisa; Cardoso Vera, Jesús Daniel; Heredía García, Gerardo; Islas Flores, Hariz; García Medina, Sandra; Galar Martínez, Marcela (Neurotoxicology, 2022-03-16)

Fluoxetine (FLX) exerts its therapeutic effect by inhibiting the presynaptic reuptake of the neurotransmitter serotonin. Nonetheless, at high concentrations of this drug, adverse effects occur in the brain of exposed or- ...
Health impact assessment after Danio rerio long-term exposure to environmentally relevant concentrations of metformin and guanylurea.

Elizalde-Velázquez, Gustavo Axel; Herrera-Vázquez, Selene Elizabeth; Gómez-Oliván, Leobardo Manuel; García-Medina, Sandra (2023-09-07)

The antidiabetic drug metformin (MET) and its metabolite guanylurea (GUA) have been frequently and ubiq- uitously detected in surface water. Consequently, there has been a consistent rise in studying the toxicity of MET ...
Integrative approach to elucidate the embryological effects of caffeine in Cyprinus carpio: Bioconcentration and alteration of oxidative stress-related gene expression patterns.

Casas Hinojosa, Idalia; Gómez Oliván, Leobardo Manuel; Gutiérrez-Noya, Verónica Margarita; García-Medina, Sandra; Rosales-Pérez, Karina Elisa; Orozco-Hernández, José Manuel; Elizalde-Velázquez, Gustavo Axel; Galar-Martínez, Marcela; Dublán-García, Octavio; Hernández-Navarro, María Dolores; Islas Flores, Hariz (Science of the Total Environment, 2023-06-20)

Caffeine (CAF) is an alkaloid, which acts as a central nervous system (CNS) stimulant drug. In recent years, CAF has been recurrently detected in water bodies, generating deleterious effects in aquatic organisms. The ...
Low concentrations of ciprofloxacin alone and in combination with paracetamol induce oxidative stress, upregulation of apoptotic-related genes, histological alterations in the liver, and genotoxicity in Danio rerio

Elizalde-Velázquez, Gustavo Axel; Rosas-Ramírez, Jonathan Ricardo; Raidúa, Demetrio; García-Medina, Sandra; Orozco-Hernández, José Manuel; Rosales-Pérez, Karina Elisa; Islas-Flores, Hariz; Galar-Martínez, Marcela; Guzmán-García, Xochitl; Gómez-Oliván, Leobardo Manuel (James Lazorchak, 2022-01-22)

Nonetheless, information regarding the toxicity of ciprofloxacin (CPX) and the CPX-PCM mixture is still limited. Herein, we aimed to evaluate the hepatotoxic and genotoxic effects that ciprofloxacin alone and in combination ...
Microplastics in aquatic environments: A review on occurrence, distribution, toxic effects, and implications for human health

Elizalde-Velázquez, Gustavo Axel; Gómez-Oliván, Leobardo Manuel (Science of the Total Environment, 2021-03-18)

Microplastics (MPs) are fragments, !bers, granules, "akes and spheres with a diameter or length of less than 5 mm. These may eventually end up in the aquatic environment by the progressive breakdown of larger plastics or ...
Oxidative stress as a potential mechanism by which guanylurea disrupts the embryogenesis of Danio rerio.

Elizalde Velázquez, Gustavo Axel; Gómez Oliván, Leobardo Manuel; Islas Flores, Hariz; Hernández Navarro, María Dolores; García Medina, Sandra; Galar Martínez, Marcela (Science of the Total Environment, 2021-08-03)

Metformin is one the most prescribed drug to treat type 2 diabetes. In wastewater treatment plants, this drug is bacterially transformed to guanylurea, which occurs at higher concentrations in the aquatic environments than ...
Polystyrene microplastics mitigate the embryotoxic damage of metformin and guanylurea in Danio rerio

Elizalde-Velázquez, Gustavo Axel; Gómez-Oliván, Leobardo Manuel; García-Medina, Sandra; Hernández-Díaz, Misael; Islas-Flores, Hariz; Galar-Martínez, Marcela; García-Medina, Alba Lucero; Chanona-Pérez, José Jorge; Hernández-Varela, Josué David (Science of the Total Environment, 2022-09-02)

Microplastics (MPs) alone may endanger the health and fitness of aquatic species through different mechanisms. How- ever, the harmful effects of these when mixed with other emerging contaminants require additional research. ...
Realistic concentrations of Bisphenol-A trigger a neurotoxic response in the brain of zebrafish: Oxidative stress, behavioral impairment, acetylcholinesterase inhibition, and gene expression disruption.

Heredia-García, Gerardo; Elizalde-Velázquez, Gustavo Axel; Gómez-Oliván, Leobardo Manuel; Islas-Flores, Hariz; García-Medina, Sandra; Galar-Martínez, Marcela; Dublán-García, Octavio (Chemosphere, 2023-04-17)

Bisphenol A (BPA) is a micro-pollutant found in various environmental matrices at concentrations as low as ng/L. Recent studies have shown that this compound can cause oxidative damage and neurotoxic effects in aquatic ...

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