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dc.contributor Gómez Oliván, Leobardo Manuel
dc.contributor.author Islas-Flores, Hariz
dc.contributor.author Gómez-Oliván, Leobardo Manuel
dc.contributor.author Galar-Martínez, Marcela
dc.contributor.author Colín-Cruz, Arturo
dc.contributor.author Neri-Cruz, Nadia
dc.contributor.author García-Medina, Sandra
dc.date 2017-03-06
dc.date.accessioned 2016-05-19T00:18:53Z
dc.date.available 2016-05-19T00:18:53Z
dc.date.issued 2013-03-06
dc.identifier.citation Hariz Islas-Flores, Leobardo Manuel Gómez-Oliván, Marcela Galar-Martínez, Arturo Colín-Cruz, Nadia Neri-Cruz, Sandra García-Medina, Diclofenac-induced oxidative stress in brain, liver, gill and blood of common carp (Cyprinus carpio), Ecotoxicology and Environmental Safety, Volume 92, 1 June 2013, Pages 32-38. es
dc.identifier.issn 0147-6513
dc.identifier.uri http://hdl.handle.net/20.500.11799/41339
dc.description Artículo científico. es
dc.description.abstract Due to its analgesic properties, diclofenac (DCF) is one of the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs). While residue from this pharmaceutical agent has been found in diverse water bodies in various countries, there is not enough information of its potential toxicity on aquatic organisms, particularly in species which are economically valuable due to their high consumption by humans, such as the common carp Cyprinus carpio. This study aimed to evaluate potential DCF-induced oxidative stress in brain, liver, gill and blood of C. carpio. The median lethal concentration of DCF at 96 h (96-h LC50) was determined and used to establish the concentration equivalent to the lowest observed adverse effect level (LOAEL). Carp specimens were exposed to this concentration for different exposure times (12, 24, 48, 72 and 96 h) and the following biomarkers were evaluated: lipid peroxidation (LPX) and the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Also, the DCF and 4-hydroxy DCF was determined by LC-MS/MS. Results show a statistically significant LPX increase (P<0.05) in liver and gill mainly as well as significant changes in the activity of the antioxidant enzymes evaluated in these organs, with respect to controls (P<0.05). The DCF concentrations decreased in water system and increased in the carp. The DCF biotransformation to 4-hydroxy DCF was observed to 12 h. The pharmaceutical agent DCF is concluded to induce oxidative stress on the common carp C. carpio, with the highest incidence of oxidative damage occurring in liver and gill. Furthermore, the biomarkers employed in this study are useful in the assessment of the environmental impact of this agent on aquatic species. es
dc.description.sponsorship This study was made possible through support from the National Science and Technology Council (CONACYT, Project 151665), as well as the Research and Postgraduate Secretariat of the National Polytechnic Institute(SIP-IPN) Project 20121226. es
dc.language.iso eng es
dc.publisher Kurunthachalam Kannan es
dc.rights embargoedAccess es
dc.subject Cyprinus carpio; Diclofenac; Lipid peroxidation; Superoxide dismutase; Catalase; Glutathione peroxidase es
dc.title Diclofenac-induced oxidative stress in brain, liver, gill and blood of common carp (Cyprinus carpio) es
dc.type Artículo es
dc.provenance Científica es
dc.road Dorada es


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  • Título
  • Diclofenac-induced oxidative stress in brain, liver, gill and blood of common carp (Cyprinus carpio)
  • Autor
  • Islas-Flores, Hariz
  • Gómez-Oliván, Leobardo Manuel
  • Galar-Martínez, Marcela
  • Colín-Cruz, Arturo
  • Neri-Cruz, Nadia
  • García-Medina, Sandra
  • Colaborador
  • Gómez Oliván, Leobardo Manuel
  • Fecha de publicación
  • 2013-03-06
  • Editor
  • Kurunthachalam Kannan
  • Tipo de documento
  • Artículo
  • Palabras clave
  • Cyprinus carpio; Diclofenac; Lipid peroxidation; Superoxide dismutase; Catalase; Glutathione peroxidase
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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