Resumen:
The available dominant water, energy, and food (WEF) technologies are responsible for the expansion of
pathogenic exposure via climate change and land change at the global scale: there are 1415 known pathogens
and 175 are emerging ones, described in the last 40 years. Expansion of xenobiotic exposure is occurring due
to the production of 250,000 compounds and an average of 4400 new ones each year. Avariety of pathogenic
and WEF xenobiotic agents affecting the human species is charted here. The basal pathogenic human
exposome (or lifelong exposure) and the anthropogenic exposome expansion are related to the human bodily
systems, to highlight concurrent damages. Foremost among interactions are cancers, which most often result
from several mutations after exposure to pathogens or xenobiotics. Of particular interest are emerging
pathogens with different bodily effects, and pathogen–xenobiotic interactions, which affect the reproductive/
endocrine/developmental systems: these systems are under anthropogenic evolutionary pressure. WEF
technologies form an intertwined nexus such that phaseout of a few dominant but obsolete technologies
can effect crucial changes in current human health trends. Prevention is of essence, which means that already
available, sustainable, technologies have to be implemented.
