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| dc.contributor.author | González-Romero, Carlos
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| dc.contributor.author | Fuentes-Benítes, Aydee
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| dc.contributor.author | Morales-Rodríguez, Macario
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| dc.contributor.author | Ramírez-Villalva, Alejandra
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| dc.contributor.author | Aguirre de Paz, José Guadalupe
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| dc.contributor.author | Morales-Reza, Marco Antonio
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| dc.contributor.author | Mejía-Dionicio, María Guadalupe
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| dc.contributor.author | González-Calderón, Davir
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| dc.date.accessioned | 2017-03-13T18:55:41Z | |
| dc.date.available | 2017-03-13T18:55:41Z | |
| dc.date.issued | 2016-09-15 | |
| dc.identifier.issn | 0045-2068 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11799/65857 | |
| dc.description.abstract | The first report of 1′-homo-N-1,2,3-triazol-bicyclic carbonucleosides (7a and 7b) is described herein. Azide-enolate (3+2) cycloaddition afforded the synthesis of this novel type of compound. Antifungal activity was evaluated in vitro against four filamentous fungi (Aspergillus fumigatus, Trichosporon cutaneum, Rhizopus oryzae and Mucor hiemalis) as well as nine species of Candida spp. as yeast specimens. These pre-clinical studies suggest that compounds 7a and 7b are promising candidates for complementary biological studies due to their good activity against Candida spp. | es |
| dc.description.sponsorship | Secretaria de Investigación y Estudios Avanzados (SIEA) de la Universidad autónoma del Estado de México (UAEMex) | es |
| dc.language.iso | eng | es |
| dc.publisher | T.D.H. Bugg | es |
| dc.rights | embargoedAccess | es |
| dc.rights | embargoedAccess | es |
| dc.subject | 1′-Homonucleosides | es |
| dc.subject | 1,2,3-Triazole | es |
| dc.subject | Antifungal activity | es |
| dc.subject | Azide-enolate cycloaddition | es |
| dc.title | Antifungal activity of 10-homo-N-1,2,3-triazol-bicyclic carbonucleosides: A novel type of compound afforded by azide-enolate (3+2) cycloaddition | es |
| dc.type | Artículo | es |
| dc.provenance | Científica | es |
| dc.road | Dorada | es |
| dc.organismo | Química | es |
| dc.ambito | Internacional | es |
| dc.cve.CenCos | 20401 | es |
| dc.cve.progEstudios | 724 | es |
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