La leptina en la carcinogénesis mamaria vías de señalización

Abstract

Abstract: High levels of leptin in obese women represent a very important risk factor to the development and progression of breast cancer. This adipocytokine acts like a growth factor in the development and progression of neoplastic cells by the activation of the signaling pathway JAK2/STAT3. Different techniques such as immunohistochemistry and RT-PCR, as well as the use of cell lines such as MCF-7 (Michigan Cancer Foundation, breast cancer cell line) have led to the understanding of the mechanisms that are activated by leptin in breast cancer. These mechanisms include several genes involved in cellular apoptosis, division and proliferation, transcription factors and angiogenesis. Obesity is now recognized as a risk factor for the development and progression of breast cancer. This review presents an overview of leptin, its receptors, its relationship with adiponectin, and the molecular mechanisms involved between obesity and breast cancer.