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dc.contributor.author Martínez Arzate, Saúl Gabriel
dc.contributor.author Sánchez Bermudez, Juan Carlos
dc.contributor.author Sotelo Gómez, Samuel
dc.contributor.author Díaz Albiter, Hector Manuel
dc.contributor.author Hegazy Hassan, Wael
dc.contributor.author Barbabosa Pliego, Alberto
dc.contributor.author Vazquez Chagoyan, Juan Carlos
dc.contributor.author Tenorio-Borroto, E.
dc.date.accessioned 2020-02-26T20:08:30Z
dc.date.available 2020-02-26T20:08:30Z
dc.date.issued 2019-07-12
dc.identifier.issn 1471-2156
dc.identifier.uri http://hdl.handle.net/20.500.11799/105874
dc.description Artículo científico derivado de Tesis doctoral de Saúl Gabriel Martínez Arzate es
dc.description.abstract Background: Ticks are a problem for cattle production mainly in tropical and subtropical regions, because they generate great economic losses. Acaricides and vaccines have been used to try to keep tick populations under control. This has been proven difficult given the resistance to acaricides and vaccines observed in ticks. Resistance to protein rBm86-based vaccines has been associated with the genetic diversity of Bm86 among the ectoparasite’s populations. So far, neither genetic diversity, nor spatial distribution of circulating Bm86 haplotypes, have been studied within the Mexican territory. Here, we explored the genetic diversity of 125 Bm86 cDNA gene sequences from R. microplus from 10 endemic areas of Mexico by analyzing haplotype distribution patterns to help in understanding the population genetic structure of Mexican ticks. Results: Our results showed an average nucleotide identity among the Mexican isolates of 98.3%, ranging from 91.1 to 100%. Divergence between the Mexican and Yeerongpilly (the Bm86 reference vaccine antigen) sequences ranged from 3.1 to 7.4%. Based on the geographic distribution of Bm86 haplotypes in Mexico, our results suggest gene flow occurrence within different regions of the Mexican territory, and even the USA. Conclusions: The polymorphism of Bm86 found in the populations included in this study, could account for the poor efficacy of the current Bm86 antigen based commercial vaccine in many regions of Mexico. Our data may contribute towards designing new, highly-specific, Bm86 antigen vaccine candidates against R. microplus circulating in Mexico. es
dc.description.sponsorship SIEAE UAEM FESE es
dc.language.iso eng es
dc.publisher BMC Genetics es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by/4.0 es
dc.subject Bm86 es
dc.subject Haplotype es
dc.subject Rhipicephalus microplus es
dc.subject Research Subject Categories::VETERINARY MEDICINE es
dc.subject.classification CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA es
dc.title Genetic diversity of Bm86 sequences in Rhipicephalus (Boophilus) microplus ticks from Mexico: analysis of haplotype distribution patterns es
dc.type Artículo es
dc.provenance Científica es
dc.road Dorada es
dc.organismo Medicina Veterinaria y Zootecnia es
dc.ambito Internacional es
dc.cve.CenCos 21401 es
dc.cve.progEstudios 764 es
dc.modalidad Artículo especializado para publicar en revista indizada es
dc.relation.vol 20
dc.relation.año 2019
dc.relation.no 56
dc.relation.doi 10.1186/s12863-019-0754-8


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  • Título
  • Genetic diversity of Bm86 sequences in Rhipicephalus (Boophilus) microplus ticks from Mexico: analysis of haplotype distribution patterns
  • Autor
  • Martínez Arzate, Saúl Gabriel
  • Sánchez Bermudez, Juan Carlos
  • Sotelo Gómez, Samuel
  • Díaz Albiter, Hector Manuel
  • Hegazy Hassan, Wael
  • Barbabosa Pliego, Alberto
  • Vazquez Chagoyan, Juan Carlos
  • Tenorio-Borroto, E.
  • Fecha de publicación
  • 2019-07-12
  • Editor
  • BMC Genetics
  • Tipo de documento
  • Artículo
  • Palabras clave
  • Bm86
  • Haplotype
  • Rhipicephalus microplus
  • Research Subject Categories::VETERINARY MEDICINE
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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