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dc.contributor.author ENRIQUEZ MEJIA, MARIA GUADALUPE
dc.contributor.author Vieyra Reyes, Patricia
dc.contributor.author TRUJILLO CONDES, VIRGILIO EDUARDO
dc.creator ENRIQUEZ MEJIA, MARIA GUADALUPE; 481212
dc.creator Vieyra Reyes, Patricia; 132206
dc.creator TRUJILLO CONDES, VIRGILIO EDUARDO; 385417
dc.date.accessioned 2022-02-24T04:28:42Z
dc.date.available 2022-02-24T04:28:42Z
dc.date.issued 2021
dc.identifier.issn N: 978-607-8695-56-0
dc.identifier.uri http://hdl.handle.net/20.500.11799/112641
dc.description.abstract Neuroglobin (NGB) is a protein with antioxidant and antiapoptotic activity against conditions such as oxidative stress, oxygen / glucose deprivation and neuronal apoptosis. Its presence has been documented in different brain areas including the midbrain, a site of key importance for global motor control by the presence of dopaminergic neurons in the substantia nigra located inside and whose progressive loss culminates in the most common neurodegenerative movement disorder, Parkinson's disease (PD). PD is a condition characterized by motor disturbances such as resting tremor, muscle rigidity, bradykinesia and deterioration gait and balance. There are few studies that inquire about the role of this protein in this disease, including its expression in the substantia nigra. The present study evaluated the presence of NGB in a murine model of PD induced by 6-OHDA injury using immunohistochemistry. The results show a significant difference of NGB aggregates in the substantia nigra in compared to controls (p=0.003) These findings provide the first in vivo experimental evidence of an adaptive NGB response in a model of PD, supporting its probable neuroprotective action in the main area involved in the pathophysiology of this disease. es
dc.description.sponsorship Instituto de Nutrición Kellogg. Kellogg Compañy es
dc.language.iso eng es
dc.publisher ECORFAN es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0
dc.subject neuroglobine es
dc.subject Parkinson disease es
dc.subject model es
dc.subject.classification MEDICINA Y CIENCIAS DE LA SALUD
dc.title Presence of neuroglobin in the substantia nigra in a murine model of parkinson´s disease: an immunohistochemical study es
dc.type Capítulo de Libro es
dc.provenance Científica es
dc.road Verde es
dc.organismo Medicina Veterinaria y Zootecnia es
dc.ambito Internacional es
dc.cve.CenCos 21402 es
dc.cve.progEstudios 716 es
dc.audience students es
dc.audience researchers es
dc.type.conacyt bookpart
dc.identificator 3
dc.relation.vol XIII


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  • Título
  • Presence of neuroglobin in the substantia nigra in a murine model of parkinson´s disease: an immunohistochemical study
  • Autor
  • ENRIQUEZ MEJIA, MARIA GUADALUPE
  • Vieyra Reyes, Patricia
  • TRUJILLO CONDES, VIRGILIO EDUARDO
  • Fecha de publicación
  • 2021
  • Editor
  • ECORFAN
  • Tipo de documento
  • Capítulo de Libro
  • Palabras clave
  • neuroglobine
  • Parkinson disease
  • model
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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