Objective. Compare the influence of ethnicity in the prevalence of osteopenia and osteoporosis in various Mexican populations using two normal dual X-ray absorptiometry (DXA) reference databases: manufacturer¿s incorporating US Hispanic population and a normal mestizo Mexican population. Material and Methods. MMP included 9 946 subjects participating in an ongoing long-term cohort study focusing on lifestyle and chronic diseases, of which 6 487 MMP males and females aged 7 to 80 years were the normal subjects used to determine bone density T- and Z-scores, following WHO criteria, and peak bone mass values. Abnormal bone mass density values estimated by the manufacturer's and peak bone mass reference values were compared. Results and Conclusions. Our results show that by using the manufacturer´s T-score values in the mestizo Mexican population we are underestimating the number of abnormal bone mass BMD populations.