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dc.contributor.author	López Durán, Fred Alonso
dc.contributor.author	PEDRAZA LOPEZ, MARTHA
dc.contributor.author	ARTEAGA PEREZ, CONSUELO
dc.contributor.author	HERNANDEZ HERNANDEZ, DIANA EDITH
dc.contributor.author	GARCIA BECERRA, ROCIO ANGELES
dc.contributor.author	ORDAZ ROSADO, DAVID
dc.creator	López Durán, Fred Alonso;#0000-0002-9316-3348
dc.creator	PEDRAZA LOPEZ, MARTHA; 25164
dc.creator	ARTEAGA PEREZ, CONSUELO; 7855
dc.creator	HERNANDEZ HERNANDEZ, DIANA EDITH; 47618
dc.creator	GARCIA BECERRA, ROCIO ANGELES; 36851
dc.creator	ORDAZ ROSADO, DAVID; 131365
dc.date.accessioned	2016-03-16T17:17:43Z
dc.date.available	2016-03-16T17:17:43Z
dc.date.issued	2009
dc.identifier	http://www.redalyc.org/articulo.oa?id=57612011002
dc.identifier.uri	http://hdl.handle.net/20.500.11799/39412
dc.description	The multistep process of angiogenesis offers several targets for therapeutic interventions. One molecular target structure is the alfa five beta three (av b3 ) integrin which is expressed on vascular endothelial cells and over-expressed in cancer tumor angiogenesis. To image neoangiogenesis in athymic mice with induced pancreatic, breast and prostate malignant tumors a new radiopharmaceutical was developed. The 99mTc-EDDA/HYNIC-cyclic-Arg-Gly- Asp-D-Phe-Lys (99mTc-cRGD) targets integrin receptors av b3 and was prepared with an average radiochemical purity > 95 %. 99mTc-cRGD shows high in vivo stability, fast blood clearance and rapid renal excretion in mice. There are statistical differences between tumor/muscle ratios for the 3 tumors studied. The highest tumor/non-target ratio was found in breast cancer (7.2 after 24 h) and a representative dorsal SPECT image was obtained where the tumor showed up very clearly over the background tissue. The high resolution of the image implies that 99mTc-cRGD will be of great value in nuclear medicine as a potential radiopharmaceutical for av b3 integrins receptor uptake and for imaging neoangiogenesis in neoplastic tissue and to follow up cancer tumor progression.
dc.format	application/pdf
dc.language.iso	eng	es
dc.publisher	Asociación Mexicana de Bioquímica Clínica, A.C.
dc.relation	http://www.redalyc.org/revista.oa?id=576
dc.rights	openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0
dc.source	Bioquimia (México) Num.2 Vol.34
dc.subject	Química	es
dc.subject	Integrin av b3	es
dc.subject	molecular imaging	es
dc.subject	angiogenesis	es
dc.subject.classification	BIOLOGÍA Y QUÍMICA
dc.title	Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice	es
dc.type	Artículo	es
dc.provenance	Científica	es
dc.road	Dorada	es
dc.ambito	Internacional	es
dc.audience	students	es
dc.audience	researchers	es
dc.type.conacyt	article
dc.identificator	2

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