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dc.contributor.author López Durán, Fred Alonso
dc.contributor.author PEDRAZA LOPEZ, MARTHA
dc.contributor.author ARTEAGA PEREZ, CONSUELO
dc.contributor.author HERNANDEZ HERNANDEZ, DIANA EDITH
dc.contributor.author GARCIA BECERRA, ROCIO ANGELES
dc.contributor.author ORDAZ ROSADO, DAVID
dc.creator López Durán, Fred Alonso;#0000-0002-9316-3348
dc.creator PEDRAZA LOPEZ, MARTHA; 25164
dc.creator ARTEAGA PEREZ, CONSUELO; 7855
dc.creator HERNANDEZ HERNANDEZ, DIANA EDITH; 47618
dc.creator GARCIA BECERRA, ROCIO ANGELES; 36851
dc.creator ORDAZ ROSADO, DAVID; 131365
dc.date.accessioned 2016-03-16T17:17:43Z
dc.date.available 2016-03-16T17:17:43Z
dc.date.issued 2009
dc.identifier http://www.redalyc.org/articulo.oa?id=57612011002
dc.identifier.uri http://hdl.handle.net/20.500.11799/39412
dc.description The multistep process of angiogenesis offers several targets for therapeutic interventions. One molecular target structure is the alfa five beta three (av b3 ) integrin which is expressed on vascular endothelial cells and over-expressed in cancer tumor angiogenesis. To image neoangiogenesis in athymic mice with induced pancreatic, breast and prostate malignant tumors a new radiopharmaceutical was developed. The 99mTc-EDDA/HYNIC-cyclic-Arg-Gly- Asp-D-Phe-Lys (99mTc-cRGD) targets integrin receptors av b3 and was prepared with an average radiochemical purity > 95 %. 99mTc-cRGD shows high in vivo stability, fast blood clearance and rapid renal excretion in mice. There are statistical differences between tumor/muscle ratios for the 3 tumors studied. The highest tumor/non-target ratio was found in breast cancer (7.2 after 24 h) and a representative dorsal SPECT image was obtained where the tumor showed up very clearly over the background tissue. The high resolution of the image implies that 99mTc-cRGD will be of great value in nuclear medicine as a potential radiopharmaceutical for av b3 integrins receptor uptake and for imaging neoangiogenesis in neoplastic tissue and to follow up cancer tumor progression.
dc.format application/pdf
dc.language.iso eng es
dc.publisher Asociación Mexicana de Bioquímica Clínica, A.C.
dc.relation http://www.redalyc.org/revista.oa?id=576
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0
dc.source Bioquimia (México) Num.2 Vol.34
dc.subject Química es
dc.subject Integrin av b3 es
dc.subject molecular imaging es
dc.subject angiogenesis es
dc.subject.classification BIOLOGÍA Y QUÍMICA
dc.title Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice es
dc.type Artículo es
dc.provenance Científica es
dc.road Dorada es
dc.ambito Internacional es
dc.audience students es
dc.audience researchers es
dc.type.conacyt article
dc.identificator 2


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  • Título
  • Radiopharmacokinetics and uptake of 99m Tc-cRGD in av B3 integrins for imaging angiogenesis in induced malignant tumors in athymic mice
  • Autor
  • López Durán, Fred Alonso
  • PEDRAZA LOPEZ, MARTHA
  • ARTEAGA PEREZ, CONSUELO
  • HERNANDEZ HERNANDEZ, DIANA EDITH
  • GARCIA BECERRA, ROCIO ANGELES
  • ORDAZ ROSADO, DAVID
  • Fecha de publicación
  • 2009
  • Editor
  • Asociación Mexicana de Bioquímica Clínica, A.C.
  • Tipo de documento
  • Artículo
  • Palabras clave
  • Química
  • Integrin av b3
  • molecular imaging
  • angiogenesis
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

Mostrar el registro sencillo del objeto digital

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