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dc.contributor.author	ORTIZ ESTRADA, CIRO HUMBERTO
dc.contributor.author	CRUZ OLIVARES, JULIAN
dc.contributor.author	PEREZ ALONSO, CESAR
dc.creator	ORTIZ ESTRADA, CIRO HUMBERTO; 120327
dc.creator	CRUZ OLIVARES, JULIAN; 69160
dc.creator	PEREZ ALONSO, CESAR; 122909
dc.date.accessioned	2016-03-16T17:18:00Z
dc.date.available	2016-03-16T17:18:00Z
dc.date.issued	2015
dc.identifier	http://www.redalyc.org/articulo.oa?id=62037106005
dc.identifier.uri	http://hdl.handle.net/20.500.11799/39512
dc.description	Coenzyme Q10 is a powerful antioxidant used on cardiovascular, neurodegenerative and cancer diseases. Its hydrophobic nature do limit its applications, because human body absorbs it with dfculty, that is why it was proposed to increase its bioavailability by diminishing the particle size using supercritical carbon dioxide. It was determined experimentally the phase behavior of the coenzyme in a supercritical system. The equilibrium data and a factorial 2k experimental design were utilized to find how the shape and size of the microparticles are affected by temperature, coQ10 concentration and nozzle diameter. Microparticles were characterized using infrared spectrometry and chromatography. For verify the fundamental chemical structure, the size and the shape of the microparticles was used scanning electronic microscopy. It was found a significant decrease in particle size and a modification of physical structure. The antioxidant power of coQ10 after micronization was measured, showing an increase of this property. Finally, in order to evaluate the bioavailability, the kinetic of solubility was determined in ethanol, having a substantial increase on solubilization speed of micronized coQ10 compared with the commercial one.
dc.format	application/pdf
dc.language.iso	eng	es
dc.publisher	Universidad Autónoma Metropolitana Unidad Iztapalapa
dc.relation	http://www.redalyc.org/revista.oa?id=620
dc.rights	Revista Mexicana de Ingeniería Química
dc.rights	openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0
dc.source	Revista Mexicana de Ingeniería Química (México) Num.1 Vol.14
dc.subject	Ingeniería	es
dc.subject	Coenzyme Q10	es
dc.subject	bioavailability	es
dc.subject	micronization	es
dc.subject	supercritical carbon dioxide	es
dc.subject.classification	INGENIERÍA Y TECNOLOGÍA
dc.title	Coenzyme q10 microparticles formation with supercritical carbon dioxide	es
dc.type	Artículo	es
dc.provenance	Científica	es
dc.road	Dorada	es
dc.ambito	Internacional	es
dc.audience	students	es
dc.audience	researchers	es
dc.type.conacyt	article
dc.identificator	7

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