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dc.contributor.author MENDOZA NAVA, HECTOR JAVIER
dc.contributor.author FERRO FLORES, GUILLERMINA
dc.contributor.author RAMIREZ DE LA CRUZ, FLOR DE MARIA
dc.contributor.author OCAMPO GARCIA, BLANCA ELI
dc.contributor.author SANTOS CUEVAS, CLARA LETICIA
dc.contributor.author ARANDA LARA, LILIANA
dc.contributor.author AZORIN VEGA, ERIKA PATRICIA
dc.contributor.author MORALES AVILA, ENRIQUE
dc.contributor.author ISAAC OLIVE, KEILA
dc.creator MENDOZA NAVA, HECTOR JAVIER; 387912
dc.creator FERRO FLORES, GUILLERMINA; 19581
dc.creator RAMIREZ DE LA CRUZ, FLOR DE MARIA; 6480
dc.creator OCAMPO GARCIA, BLANCA ELI; 309879
dc.creator SANTOS CUEVAS, CLARA LETICIA; 171596
dc.creator ARANDA LARA, LILIANA; 473137
dc.creator AZORIN VEGA, ERIKA PATRICIA; 49309
dc.creator MORALES AVILA, ENRIQUE; 170668
dc.creator ISAAC OLIVE, KEILA; 243975
dc.date.accessioned 2017-03-10T15:42:39Z
dc.date.available 2017-03-10T15:42:39Z
dc.date.issued 2016-06-29
dc.identifier.issn 1687-4110
dc.identifier.uri http://hdl.handle.net/20.500.11799/65730
dc.description.abstract 177Lu-labeled nanoparticles conjugated to biomolecules have been proposed as a new class of theranostic radiopharmaceuticals. The aim of this research was to synthesize 177Lu-dendrimer(PAMAM-G4)-folate-bombesin with gold nanoparticles (AuNPs) in the dendritic cavity and to evaluate the radiopharmaceutical potential for targeted radiotherapy and the simultaneous detection of folate receptors (FRs) and gastrin-releasing peptide receptors (GRPRs) overexpressed in breast cancer cells. p-SCN-Benzyl-DOTA was conjugated in aqueous-basic medium to the dendrimer.The carboxylate groups of Lys1Lys3(DOTA)-bombesin and folic acid were activatedwithHATUand also conjugated to the dendrimer.The conjugate was mixed with 1%HAuCl4 followed by the addition of NaBH4 and purified by ultrafiltration. Elemental analysis (EDS), particle size distribution (DLS), TEM analysis, UV-Vis, and infrared and fluorescence spectroscopies were performed. The conjugate was radiolabeled using 177LuCl3 or 68GaCl3 and analyzed by radio-HPLC. Studies confirmed the dendrimer functionalization with high radiochemical purity (>95%). Fluorescence results demonstrated that the presence ofAuNPs in the dendritic cavity confers useful photophysical properties to the radiopharmaceutical for optical imaging. Preliminary binding studies in T47D breast cancer cells showed a specific cell uptake (41.15 ± 2.72%). 177Ludendrimer( AuNP)-folate-bombesin may be useful as an optical and nuclear imaging agent for breast tumors overexpressing GRPR and FRs, as well as for targeted radiotherapy. es
dc.description.sponsorship CONACYT-SEP-CB-2014-01-242443 International Atomic Energy Agency (Grant 18358) LaboratorioNacional de Investigaci´on yDesarrollo de Radiof´armacos, CONACyT es
dc.language.iso eng es
dc.rights openAccess es
dc.rights.uri http://creativecommons.org/licenses/by/4.0
dc.subject Dendrimers es
dc.subject Gold nanoparticles es
dc.subject Theranostic Radiopharmaceutical es
dc.subject.classification BIOLOGÍA Y QUÍMICA
dc.title 177Lu-Dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity: A potential theranostic radiopharmaceutical es
dc.type Artículo es
dc.provenance Científica es
dc.road Dorada es
dc.ambito Internacional es
dc.cve.CenCos 20201 es
dc.cve.progEstudios 746 es
dc.modalidad Artículo especializado para publicar en revista indizada es
dc.audience students
dc.audience researchers
dc.type.conacyt article
dc.identificator 2


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  • Título
  • 177Lu-Dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity: A potential theranostic radiopharmaceutical
  • Autor
  • MENDOZA NAVA, HECTOR JAVIER
  • FERRO FLORES, GUILLERMINA
  • RAMIREZ DE LA CRUZ, FLOR DE MARIA
  • OCAMPO GARCIA, BLANCA ELI
  • SANTOS CUEVAS, CLARA LETICIA
  • ARANDA LARA, LILIANA
  • AZORIN VEGA, ERIKA PATRICIA
  • MORALES AVILA, ENRIQUE
  • ISAAC OLIVE, KEILA
  • Fecha de publicación
  • 2016-06-29
  • Tipo de documento
  • Artículo
  • Palabras clave
  • Dendrimers
  • Gold nanoparticles
  • Theranostic Radiopharmaceutical
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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