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dc.contributor.author Gómez-Oliván, Leobardo Manuel
dc.contributor.author Mendoza-Zenil, Youssef Paolo
dc.contributor.author SanJuan-Reyes, Nely
dc.contributor.author Galar-Martínez, Marcela
dc.contributor.author Ramírez-Durán, Ninfa
dc.contributor.author Rodríguez Martín-Doimeadios, Rosa del Carmén
dc.contributor.author Rodríguez-Fariñas, Nuria
dc.contributor.author Islas-Flores, Hariz
dc.contributor.author Elizalde-Velázquez, Armando
dc.contributor.author García-Medina, Sandra
dc.contributor.author Pérez-Pastén Borja, Ricardo
dc.date.accessioned 2017-11-07T01:33:19Z
dc.date.available 2017-11-07T01:33:19Z
dc.date.issued 2016-10-07
dc.identifier.issn 0147-6513
dc.identifier.uri http://hdl.handle.net/20.500.11799/67574
dc.description.abstract Metals such as Al, Fe and Hg are used in diverse anthropogenic activities. Their presence in water bodies is due mainly to domestic, agricultural and industrial wastewater discharges and constitutes a hazard for the organisms inhabiting these environments. The present study aimed to evaluate geno- and cyto- toxicity induced by Al, Fe, Hg and the mixture of these metals on blood of the common carp Cyprinus carpio. Specimens were exposed to the permissible limits in water for human use and consumption according to the pertinent official Mexican norm [official Mexican norm NOM-127-SSA1-1994] Al (0.2 mg L 1), Fe (0.3 mg L 1), Hg (0.001 mg L 1) and their mixture for 12, 24, 48, 72 and 96 h. Bio- markers of genotoxicity (comet assay and micronucleus test) and cytotoxicity (caspase-3 activity and TUNEL assay) were evaluated. Significant increases relative to the control group (po0.05) were observed in all biomarkers at all exposure times in all test systems; however, damage was greater when the metals were present as a mixture. Furthermore, correlations between metal concentrations and biomarkers of geno- and cytotoxicity were found only at certain exposure times. In conclusion, Al, Fe, Hg and the mixture of these metals induce geno- and cytotoxicity on blood of C. carpio. es
dc.description.sponsorship CONACyT-Mexico, Project 181541 es
dc.language.iso eng es
dc.rights embargoedAccess es
dc.rights No aplica es
dc.rights embargoedAccess es
dc.rights No aplica es
dc.subject Heavy metals es
dc.subject DNA damage es
dc.subject Apoptosis es
dc.title Geno-and cytotoxicity induced on Cyprinus carpio by aluminum, iron, mercury and mixture thereof. es
dc.type Artículo es
dc.provenance Científica es
dc.road Dorada es
dc.organismo Química es
dc.ambito Internacional es
dc.cve.CenCos 20401 es
dc.cve.progEstudios 657 es


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  • Título
  • Geno-and cytotoxicity induced on Cyprinus carpio by aluminum, iron, mercury and mixture thereof.
  • Autor
  • Gómez-Oliván, Leobardo Manuel
  • Mendoza-Zenil, Youssef Paolo
  • SanJuan-Reyes, Nely
  • Galar-Martínez, Marcela
  • Ramírez-Durán, Ninfa
  • Rodríguez Martín-Doimeadios, Rosa del Carmén
  • Rodríguez-Fariñas, Nuria
  • Islas-Flores, Hariz
  • Elizalde-Velázquez, Armando
  • García-Medina, Sandra
  • Pérez-Pastén Borja, Ricardo
  • Fecha de publicación
  • 2016-10-07
  • Tipo de documento
  • Artículo
  • Palabras clave
  • Heavy metals
  • DNA damage
  • Apoptosis
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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