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dc.contributor.author	MARTINEZ DOMINGUEZ, ANABELLA
dc.contributor.author	CONTRERAS YANEZ, IRAZU
dc.contributor.author	ESTRADA GUADARRAMA, JOSE ANTONIO
dc.creator	MARTINEZ DOMINGUEZ, ANABELLA; 366002
dc.creator	CONTRERAS YANEZ, IRAZU; 176001
dc.creator	ESTRADA GUADARRAMA, JOSE ANTONIO; 103917
dc.date.accessioned	2019-01-17T23:41:18Z
dc.date.available	2019-01-17T23:41:18Z
dc.date.issued	2017
dc.identifier	http://www.redalyc.org/articulo.oa?id=41654732008
dc.identifier.uri	http://hdl.handle.net/20.500.11799/96909
dc.description	Oxidative stress (OS) is considered a risk factor for neurodegenerative disorders. Iron concentrations have been related to OS; however, the effect of iron deficiency (ID) on the induction of OS in the central nervous system (CNS) is unknown. A murine model of chronic diet-induced ID using 2 month-old male BALB/c mice (6 specimen), was used to determine its role in OS induction. Lipid peroxidation was determined by measuring thiobarbituric acid-reactive species (TBARS) in the CNS, using the spleen for comparison. A decrease of peroxidation products in the CNS of the ID group (ID CNS), compared to controls fed on a regular diet, was found. The spleen showed a significant increase of lipid peroxidation in the ID group. Our results suggest that chronic ID may have differential effects on OS in the CNS and peripheral tissues. A decreased amount of reactive oxygen species in the basal state may be related to alterations on normal CNS metabolism and functions under chronic ID.
dc.format	application/pdf
dc.language.iso	eng	es
dc.publisher	Universidad de Guanajuato
dc.relation	http://www.redalyc.org/revista.oa?id=416
dc.rights	Acta Universitaria
dc.rights	openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0
dc.source	Acta Universitaria (México) Num.6 Vol.27
dc.subject	Multidisciplinarias (Ciencias Sociales)
dc.subject	Oxidative stress
dc.subject	lipid peroxidation
dc.subject	iron deficiency
dc.subject	central nervous system
dc.subject	spleen
dc.subject	Multidisciplinarias (Ciencias Sociales)	es
dc.subject	Oxidative stress	es
dc.subject	lipid peroxidation	es
dc.subject	iron deficiency	es
dc.subject	central nervous system	es
dc.subject	spleen	es
dc.subject.classification	CIENCIAS SOCIALES
dc.title	Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice
dc.title	Oxidative damage in lipids in the central nervous system and spleen in iron-deficient mice	es
dc.type	Artículo
dc.type	Artículo	es
dc.road	Dorada	es
dc.ambito	Nacional	es
dc.audience	students	es
dc.audience	researchers	es
dc.type.conacyt	article
dc.identificator	5

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