Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2

CHAVEZ MONTEAGUDO, JULIO RAUL; Ibancovichi Camarillo, José Antonio; RECILLAS MORALES, SERGIO; SANCHEZ APARICIO, PEDRO; OSORIO AVALOS, JORGE; DE PAZ CAMPOS, MARCO ANTONIO

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dc.contributor.author	CHAVEZ MONTEAGUDO, JULIO RAUL
dc.contributor.author	Ibancovichi Camarillo, José Antonio
dc.contributor.author	RECILLAS MORALES, SERGIO
dc.contributor.author	SANCHEZ APARICIO, PEDRO
dc.contributor.author	OSORIO AVALOS, JORGE
dc.contributor.author	DE PAZ CAMPOS, MARCO ANTONIO
dc.creator	CHAVEZ MONTEAGUDO, JULIO RAUL; 441813
dc.creator	Ibancovichi Camarillo, José Antonio; 251955
dc.creator	RECILLAS MORALES, SERGIO; 171765
dc.creator	SANCHEZ APARICIO, PEDRO; 168298
dc.creator	OSORIO AVALOS, JORGE; 174423
dc.creator	DE PAZ CAMPOS, MARCO ANTONIO; 216438
dc.date.accessioned	2023-02-15T00:24:23Z
dc.date.available	2023-02-15T00:24:23Z
dc.date.issued	2022-03-29
dc.identifier.issn	2076-2615
dc.identifier.uri	http://hdl.handle.net/20.500.11799/137855
dc.description	articulo cientifico open acces	es
dc.description.abstract	The minimum alveolar concentration MAC of isoflurane was measured in rats chronically treated with WIN 55,212-2. Methods: The MAC of isoflurane was determined in 24 male rats from expiratory samples at time of tail clamping under the following conditions: without treatment MAC(ISO), in rats treated for 21 days with WIN 55,212-2 MAC(ISO + WIN55), and in rats 8 days after stopping treatment with WIN 55,212-2 (MACISO + WIN55 + 8D). Results: The MAC(ISO) was 1.32 0.06. In the MAC(ISO + WIN55) group, the MAC increased to 1.69 0.09 (28%, p-value (0.0001). Eight days after stopping treatment with WIN55, the MAC did not decrease significantly, 1.67 0.07 (26%, p-value 0.0001). Conclusions: The administration of WIN 55,212-2 for 21 days increases the MAC of isoflurane in rats. This effect does not disappear 8 days after discontinuation of treatment with the synthetic cannabinoid.	es
dc.language.iso	eng	es
dc.publisher	MDPI	es
dc.rights	openAccess	es
dc.rights.uri	http://creativecommons.org/licenses/by/4.0	es
dc.subject	minimum alveolar concentration	es
dc.subject	MAC	es
dc.subject	isoflurane	es
dc.subject	WIN 55,212-2	es
dc.subject	rats	es
dc.subject.classification	CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA	es
dc.title	Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2	es
dc.type	Artículo	es
dc.provenance	Científica	es
dc.road	Dorada	es
dc.organismo	Medicina Veterinaria y Zootecnia	es
dc.ambito	Internacional	es
dc.cve.CenCos	21401	es
dc.cve.progEstudios	2	es
dc.audience	students	es
dc.audience	researchers	es
dc.type.conacyt	article
dc.identificator	6
dc.relation.vol	12

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Título
Minimum Alveolar Concentration of Isoflurane in Rats Chronically Treated with the Synthetic Cannabinoid WIN 55,212-2
Autor
CHAVEZ MONTEAGUDO, JULIO RAUL
Ibancovichi Camarillo, José Antonio
RECILLAS MORALES, SERGIO
SANCHEZ APARICIO, PEDRO
OSORIO AVALOS, JORGE
DE PAZ CAMPOS, MARCO ANTONIO
Fecha de publicación
2022-03-29
Editor
MDPI
Tipo de documento
Artículo
Palabras clave
minimum alveolar concentration
MAC
isoflurane
WIN 55,212-2
rats

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