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dc.contributor.author Pérez-Coyotl, Isabel
dc.contributor.author Martínez-Vieyra, Catalina
dc.contributor.author Galar-Martínez, Marcela
dc.contributor.author Gómez-Oliván, Leobardo Manuel
dc.contributor.author García-Medina, Sandra
dc.contributor.author Islas-Flores, Hariz
dc.contributor.author Pérez-Pastén Borja, Ricardo
dc.contributor.author Gasca-Pérez, Eloy
dc.contributor.author Novoa-Luna, Karen Adriana
dc.contributor.author Dublán-García, Octavio
dc.date.accessioned 2017-11-07T01:41:36Z
dc.date.available 2017-11-07T01:41:36Z
dc.date.issued 2017-07-18
dc.identifier.issn 0045-6535
dc.identifier.uri http://hdl.handle.net/20.500.11799/67577
dc.description Artículo científico es
dc.description.abstract Madín Reservoir provides a substantial amount of drinking water to two municipalities close to Mexico City metropolitan area. However, it receives untreated wastewater discharges from domestic sources in the towns of Nuevo Madín and others, as well as diverse pollutants which are hauled by the Río Tlal- nepantla from its upper reaches, so that the xenobiotics in the reservoir are highly diverse in terms of type and quantity. Previous studies showed that MR is contaminated with xenobiotics such as Al, Hg and Fe, as well as NSAIDs, at concentrations exceeding the limits established for aquatic life protection. These pollutants have been shown to induce oxidative stress on Cyprinus carpio and may therefore also damage the genetic material of exposed organisms, eliciting cytotoxicity as well. The present study aimed to determine the genotoxicity and cytotoxicity induced on blood, liver and gill of C. carpio by the pollutants present in MR water. Specimens were exposed to water from five sampling sites and the following biomarkers were evaluated: DNA damage by comet assay, frequency of micronuclei, apoptosis by TUNEL assay and caspase-3 activity. Significant increases relative to the control group (P < 0.05) were found with all biomarkers in all tissues evaluated, with the level of damage differing between sampling sites. In conclusion, pollutants present in MR water are genotoxic and cytotoxic to C. carpio, and this sentinel species, coupled with the biomarkers evaluated herein, is a reliable tool for assessing the health risk to wildlife posed by exposure to pollutants in freshwater bodies. es
dc.description.sponsorship Consejo Nacional de Ciencia y Tecnología (CONACyT-Mexico, Proj- ect 181541), and the Secretaría de Investigacio n y Posgrado, Insti- tuto Polite cnico Nacional (SIP-IPN, proyecto 20160871). es
dc.language.iso eng es
dc.publisher Jacob de Boer, Shane Snyder es
dc.relation.ispartofseries 185;789-797
dc.rights embargoedAccess es
dc.rights No aplica es
dc.rights embargoedAccess es
dc.rights No aplica es
dc.subject Artículo científico es
dc.title DNA damage and cytotoxicity induced on common carp by pollutants in water from an urban reservoir. Madín reservoir, a case study es
dc.type Artículo es
dc.provenance Científica es
dc.road Verde es
dc.organismo Química es
dc.ambito Internacional es
dc.cve.CenCos 20401 es
dc.modalidad Artículo especializado para publicar en revista indizada es


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  • Título
  • DNA damage and cytotoxicity induced on common carp by pollutants in water from an urban reservoir. Madín reservoir, a case study
  • Autor
  • Pérez-Coyotl, Isabel
  • Martínez-Vieyra, Catalina
  • Galar-Martínez, Marcela
  • Gómez-Oliván, Leobardo Manuel
  • García-Medina, Sandra
  • Islas-Flores, Hariz
  • Pérez-Pastén Borja, Ricardo
  • Gasca-Pérez, Eloy
  • Novoa-Luna, Karen Adriana
  • Dublán-García, Octavio
  • Fecha de publicación
  • 2017-07-18
  • Editor
  • Jacob de Boer, Shane Snyder
  • Tipo de documento
  • Artículo
  • Palabras clave
  • Artículo científico
  • Los documentos depositados en el Repositorio Institucional de la Universidad Autónoma del Estado de México se encuentran a disposición en Acceso Abierto bajo la licencia Creative Commons: Atribución-NoComercial-SinDerivar 4.0 Internacional (CC BY-NC-ND 4.0)

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